Evidence map›Paper›PMID 40909351›Full record

ReviewJournal of cell communication and signaling2025

The structure, function, and distribution of gap junctions in the retina: Life cycle in health and disease.

Anna Pacwa, Klaudia Mroz, Xiaonan Liu, Adrian Smedowski

Abstract readReview
In one paragraph

Review in Journal of cell communication and signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna PacwaDepartment of Opthalmology Faculty of Medical Sciences in Katowice The Laboratory for Translational Research in Ophthalmology Medical University of Silesia Katowice Poland.
Klaudia MrozDepartment of Opthalmology Faculty of Medical Sciences in Katowice The Laboratory for Translational Research in Ophthalmology Medical University of Silesia Katowice Poland.ORCID https://orcid.org/0000-0003-3830-1741
Xiaonan LiuDepartment of Opthalmology Faculty of Medical Sciences in Katowice The Laboratory for Translational Research in Ophthalmology Medical University of Silesia Katowice Poland.
Adrian SmedowskiDepartment of Opthalmology Faculty of Medical Sciences in Katowice The Laboratory for Translational Research in Ophthalmology Medical University of Silesia Katowice Poland.ORCID https://orcid.org/0000-0001-8528-955X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gap junctions are essential channels of communication between cells including neurons in the central nervous system. These channels coordinate cell metabolic and electrical functions including such crucial ones for maintaining homeostasis as cell proliferation, differentiation, survival, and apoptosis. They create narrow passageways that allow rapid exchange of small molecules, ions, and secondary messengers between neighboring cells including the retina and optic nerve. Disruption in normal functioning of gap junctions may result in various neurodegenerative disorders. A comprehensive understanding of gap junction composition, function, and regulation is the key in determining novel approaches to neuroprotection and neuroregeneration. Here, we review the structure and the role of gap junctions in the retina and discuss the life cycle of connexins and their involvement in retinal neurodegenerations.

Indexed as

connexinselectrical synapsesgap junctionsintercellular communicationneurodegenerative diseases

Identifiers

PMID40909351
PMCPMC12408185

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.