Evidence map›Paper›PMID 40909447›Full record

ReviewFrontiers in medicine2025

Categories, applications, and potential of stem cells in bone regeneration: an overview.

Mingyang Jiao, Ting Shuai, Zhongfang Zhao, Yuwei Wu, Linwei Yu, Jingwen Sun, Raffaele De Caro, Veronica Macchi, Andrea Porzionato, Elena Stocco and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mingyang Jiao *Beijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, Department of Prosthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.
Ting Shuai *The Second Clinical Division of Peking University School and Hospital of Stomatology, Beijing, China.
Zhongfang Zhao *Hospital of Stomatology, Lanzhou University, Lanzhou, China.
Yuwei WuThe Second Clinical Division of Peking University School and Hospital of Stomatology, Beijing, China.
Linwei YuBeijing Key Laboratory of Digital Stomatology, NHC Key Laboratory of Digital Stomatology, NMPA Key Laboratory for Dental Materials, Department of Prosthodontics, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, Beijing, China.
Jingwen SunSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Raffaele De CaroSection of Human Anatomy, Department of Neuroscience, University of Padova, Padua, Italy.
Veronica MacchiSection of Human Anatomy, Department of Neuroscience, University of Padova, Padua, Italy.
Andrea PorzionatoSection of Human Anatomy, Department of Neuroscience, University of Padova, Padua, Italy.
Elena Stocco *Section of Human Anatomy, Department of Neuroscience, University of Padova, Padua, Italy.
Chanyuan Jin *The Second Clinical Division of Peking University School and Hospital of Stomatology, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects affect many individuals globally and can result in significant suffering and impairment, particularly among the elderly population. In addition, current treatment options for critical-size bone defects, such as autologous or allogeneic bone graft transplantation, present significant challenges. Within this clinical scenario the identification of novel and effective approaches for bone regeneration is urgently needed, and options derived from tissue engineering may be particularly appealing. Bone tissue engineering for bone regeneration involves the application of seed cells, growth factors, and biomaterials to create bioactive substitutes for repairing bone defects. In recent decades, advancements in stem cell research and biological biomaterials have led to remarkable breakthroughs in the field of bone regeneration. In particular, various categories of stem cells have been isolated, characterized, and employed in tissue engineering approaches. This review summarizes the applications of the main types of stem cells currently used for bone regeneration through tissue engineering approaches, and it also pays attention to the most appealing materials for it.

Indexed as

biomaterialsbone regenerationbone tissue engineeringosteogenic differentiationregenerative medicinestem cells

Identifiers

PMID40909447
PMCPMC12406871

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.