Evidence map›Paper›PMID 40909485›Full record

ArticlebioRxiv : the preprint server for biology2025

Widespread purine bias in bacterial genes driven by runaway transcription.

K Julia Dierksheide, James C Taggart, Grace E Johnson, Gene-Wei Li

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

K Julia DierksheideDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0009-0004-0946-2655
James C TaggartDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Grace E JohnsonDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Gene-Wei LiDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

Funding

Evolution and Regulation of Bacterial Proteome CompositionR35GM124732 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Gene-Wei Li · 2017 to 2026
$3.8M
NIGMS NIH HHS R35 GM124732
6 · The paper itself

Abstract

Genes in many bacteria are rich in purine nucleotides and poor in pyrimidines. We show that this purine preference is critical for gene expression because it prevents premature transcription termination in species that exhibit runaway transcription. In contrast to coupled transcription-translation

Identifiers

PMID40909485
PMCPMC12407708

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.