Evidence map›Paper›PMID 40909525›Full record

ArticlebioRxiv : the preprint server for biology2025

Identifying a Vaginal Microbiome-Derived Selective Antibiotic Metabolite via Microbiome Pharmacology Analysis.

Smrutiti Jena, Damilola Lawore, Javier Muñoz Briones, Kenzie Birse, Alana Lamont, Romel D Mackelprang, Laura Noel-Romas, Michelle Perner, Xuanlin Hou, Elizabeth Irungu and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Smrutiti JenaWeldon School of Biomedical Engineering, Purdue University, West Lafayette IN.
Damilola LaworeWeldon School of Biomedical Engineering, Purdue University, West Lafayette IN.ORCID 0009-0008-2171-6565
Javier Muñoz BrionesWeldon School of Biomedical Engineering, Purdue University, West Lafayette IN.ORCID 0009-0003-1129-8105
Kenzie BirseDepartment of Obstetrics and Gynecology, University of Manitoba, Winnipeg Canada.
Alana LamontDepartment of Obstetrics and Gynecology, University of Manitoba, Winnipeg Canada.
Romel D MackelprangDepartment of Global Health, University of Washington, Seattle USA.
Laura Noel-RomasDepartment of Obstetrics and Gynecology, University of Manitoba, Winnipeg Canada.
Michelle PernerMedical Microbiology and Infectious Disease University of Manitoba, Winnipeg Canada.
Xuanlin HouDepartment of Global Health, University of Washington, Seattle USA.
Elizabeth IrunguPartners in Health Research and Development, Kenya Medical Research Institute, Nairobi Kenya.
Nelly MugoDepartment of Global Health, University of Washington, Seattle USA.
Samantha KnodelDepartment of Obstetrics and Gynecology, University of Manitoba, Winnipeg Canada.
Stephanie Doran BrubakerGraduate School of Public Health, University of Pittsburgh, Pittsburgh USA.ORCID 0009-0008-5928-4788
Timothy R MuwongeInfectious Disease Institute, Makerere University, Makerere, Kampala Uganda.
Elly KatabiraInfectious Disease Institute, Makerere University, Makerere, Kampala Uganda.
Sean M HughesDepartment of Obstetrics and Gynecology, University of Washington, Seattle USA.
Fernanda L CalienesFred Hutchinson Cancer Research Center, Seattle USA.
Raymond KrajciCenter for Global Health and Disease, Department of Pathology, Case Western Reserve University, Cleveland OH.ORCID 0000-0002-4512-5363
Rachel LiuCenter for Global Health and Disease, Department of Pathology, Case Western Reserve University, Cleveland OH.
Dalí NemecioCenter for Global Health and Disease, Department of Pathology, Case Western Reserve University, Cleveland OH.ORCID 0000-0002-2263-3904
Florian HladikDepartment of Obstetrics and Gynecology, University of Washington, Seattle USA.ORCID 0000-0002-0375-2764
Jairam LingappaDepartment of Global Health, University of Washington, Seattle USA.
Adam D BurgenerDepartment of Obstetrics and Gynecology, University of Manitoba, Winnipeg Canada.ORCID 0000-0002-2303-5738
Alicia R BerardDepartment of Obstetrics and Gynecology, University of Manitoba, Winnipeg Canada.ORCID 0000-0002-2210-0577
Leopold N GreenWeldon School of Biomedical Engineering, Purdue University, West Lafayette IN.ORCID 0000-0001-5479-6970
Douglas K BrubakerCenter for Global Health and Disease, Department of Pathology, Case Western Reserve University, Cleveland OH.ORCID 0000-0001-5083-0334

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
The role of the female and male reproductive microenvironment in fertility fitnessR01HD110367 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI Douglas Brubaker, Christina FARR ZUEND · 2023 to 2026
$2.3M
Quantifying the impact of genital mucosal inflammation on HIV-1 acquisition riskR01AI111738 · NIAID · UNIVERSITY OF WASHINGTON · PI LINGAPPA, JAIRAM RAO · 2014 to 2017
$2.3M
NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI111738NICHD NIH HHS R01 HD110367
6 · The paper itself

Abstract

The vaginal microbiome plays a critical role in maintaining immune and epithelial homeostasis in the female reproductive tract. Bacterial Vaginosis (BV) is deleterious to female health, causing the loss of beneficial

Identifiers

PMID40909525
PMCPMC12407940

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.