Evidence map›Paper›PMID 40909656›Full record

ArticlebioRxiv : the preprint server for biology2025

B12 promotes gut dysbiosis and an inflammatory microenvironment that potentiates

P D Lyon, T E Leesang, J P Brabson, Ktt Do, M Dalzell, L A Nivelo, M Q Lam, A Peci, B Fang, V Strippoli and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

P D LyonMedical Scientist Training Program, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
T E LeesangCancer Epigenetics Program, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
J P BrabsonCancer Epigenetics Program, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
Ktt DoCancer Epigenetics Program, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
M DalzellDepartment of Microbiology & Immunology, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
L A NiveloDepartment of Microbiology & Immunology, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
M Q LamCancer Epigenetics Program, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
A PeciCancer Epigenetics Program, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
B FangCancer Epigenetics Program, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
V StrippoliCancer Epigenetics Program, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
A A ArmandCancer Epigenetics Program, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
P K SinghDepartment of Surgery, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
S RoyDepartment of Surgery, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.ORCID 0000-0002-6192-8289
F BeckedorffCancer Epigenetics Program, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.ORCID 0000-0001-6735-6851
A V VillarinoDepartment of Microbiology & Immunology, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.
L CimminoCancer Epigenetics Program, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, 33136 USA.ORCID 0000-0002-4218-582X

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2019 to 2026
$24.1M
Enhancing TET activity for the treatment of hematological malignancyR01CA282453 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Luisa Cimmino · 2023 to 2026
$1.4M
NCI NIH HHS P30 CA240139NCI NIH HHS R01 CA282453
6 · The paper itself

Abstract

Recent studies have linked elevated vitamin B12 serum levels with the presence of clonal hematopoiesis (CH) and an increased risk of developing myeloid malignancy. High B12 supplementation increases serum levels, alters gut microbial composition, and reduces the production of short-chain fatty acids (SCFAs), which help maintain gut barrier function and mucosal integrity.

Identifiers

PMID40909656
PMCPMC12407742

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.