Evidence map›Paper›PMID 40909751›Full record

ArticlebioRxiv : the preprint server for biology2025

Multiomic Analysis Reveals Molecular Pathways Associated with Intestinal Aggregation of α-Synuclein.

Julia M Balsamo, Ying Yan, Dylan Thai, Stephanie M Cologna, Elizabeth N Bess

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Julia M BalsamoDepartment of Chemistry, University of California, Irvine, CA 92617, USA.
Ying YanDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.
Dylan ThaiDepartment of Chemistry, University of California, Irvine, CA 92617, USA.
Stephanie M ColognaDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-3541-3361
Elizabeth N BessDepartment of Chemistry, University of California, Irvine, CA 92617, USA.ORCID 0000-0003-0349-0423

Funding

Discovery of Chemical Factors in the Gut Microbiome that Control Alpha-Synuclein Aggregation in Parkinson's DiseaseR01NS138879 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Elizabeth Nancy Bess · 2024 to 2026
$1.4M
NINDS NIH HHS R01 NS138879
6 · The paper itself

Abstract

Aggregates of the protein α-synuclein may initially form in the gut before propagating to the brain in Parkinson's disease. Indeed, our prior work supports that enteroendocrine cells, specialized intestinal epithelial cells, could play a key role in the development of this disease. Enteroendocrine cells natively express α-synuclein and synapse with enteric neurons as well as the vagus nerve. Severing the vagus nerve reduces the load of α-synuclein aggregates in the brain, suggesting that this nerve is a conduit for gut-to-brain spread. Enteroendocrine cells line the gut lumen, as such, they are in constant contact with metabolites of the gut microbiota. We previously found that when enteroendocrine cells are exposed to nitrite-a potent oxidant produced by gut bacterial

Indexed as

dopamineenteroendocrine cellsgut microbiomenitriteParkinson’s diseaseROSα-synuclein

Identifiers

PMID40909751
PMCPMC12407913

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.