Evidence map›Paper›PMID 40909759›Full record

ArticleJPRAS open2025

Effectiveness of injected versus topically applied platelet-rich plasma in diabetic foot ulcers: A randomized controlled trial with clinical and histopathological assessment.

Mohamed Nasr, Moustafa Ah El-Nawasany, Haytham E Ali, Ahmed E El Nagar, Ayman F Elsharawy, Dahlia Soleman A Mirdad, Razan Abed A Baloush, Mohammed Ali Majrashi, Mohamed Hassan Elkaseer, Mohammed A Abdel-Maksoud and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JPRAS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mohamed NasrHistology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Moustafa Ah El-NawasanyHistology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Haytham E AliHistology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ahmed E El NagarHistology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ayman F ElsharawyHistology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Dahlia Soleman A MirdadDepartment of Basic Medical Sciences, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Razan Abed A BaloushDepartment of Basic Medical Sciences, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Mohammed Ali MajrashiDepartment of Basic Medical Sciences, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
Mohamed Hassan ElkaseerGeneral Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohammed A Abdel-MaksoudGeneral Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohammad Omar MahmoudGeneral Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Zahraa Futooh MohammedGeneral Surgery Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Hany Sabry A IbrahimDermatology, Venerology and Andrology, International Islamic center of population studies and research, Al-Azhar University, Cairo, Egypt.
Tahseen S MohammedPublic Health and Community Medicine Department, Faculty of Medicine, Al- Azhar University, Cairo, Egypt.
Abdulkarim HasanPathology Department, Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
Ashraf Yahia HegabInternal Medicine Department, Prince Mishari bin Saud Hospital in Baljurashi, Al-Baha Health Cluster, Ministry of Health, Al-Baha, Saudi Arabia.
Khaldon Abdulrahman A AlaghbariPlastic Surgery Department, Prince Mishari bin Saud Hospital in Baljurashi, Al-Baha Health Cluster, Ministry of Health, Al-Baha, Saudi Arabia.
Mohammed AbbasGeneral Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Hashem Bark A AboodSurgery Department, King Fahad Hospital, Al-Baha Health Cluster, Ministry of Health, Al-Baha, Saudi Arabia.
Mohamad Ghazy A HablasHistology and Cell Biology Department, Faculty of Medicine, Suez University, Suez, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes that can lead to significant morbidity. Autologous platelet-rich plasma (PRP), rich in growth factors and cytokines, has emerged as a promising treatment to enhance ulcer healing. This study aimed to compare the clinical and histological efficacy of injected PRP versus topically applied PRP and traditional wound care in the management of DFUs. Methods: Sixty patients with DFUs were randomly assigned to three equal groups ( Results: By the end of the 12-week follow-up, 87.5 % of patients treated with PRP (35 out of 40 in Groups A and B) achieved complete ulcer healing, compared to a significantly lower healing rate in the traditional care group (Group C). Histological findings supported the clinical outcomes. No significant difference was found between injected and topically applied PRP in terms of clinical effectiveness. Conclusion: PRP treatment, whether injected or topically applied, significantly enhances the healing of DFUs compared to traditional wound care. Both methods of PRP application demonstrated comparable clinical efficacy.

Indexed as

Diabetic foot ulcerHistopathologyPlatelet-rich plasma (PRP)Topical PRPWound healing

Identifiers

PMID40909759
PMCPMC12405637

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.