Evidence map›Paper›PMID 40909773›Full record

ArticleResearch square2025

mRNA vaccines encoding variant forms of Sm-TSP-2 confer protective immunity against Schistosoma mansoni.

Athos Silva Oliveira, Sevan Alwan, Philip T LoVerde, Ramiz Shaheed, Pranav Mandyam, Rakesh Adhikari, Peter Hotez, Maria Elena Bottazzi, Jeroen Pollet

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Athos Silva OliveiraNational School of Tropical Medicine, Baylor College of Medicine.
Sevan AlwanUniversity of Texas Health Science Center.
Philip T LoVerdeUniversity of Texas Health Science Center.
Ramiz ShaheedUniversity of Texas Health Science Center.
Pranav MandyamNational School of Tropical Medicine, Baylor College of Medicine.
Rakesh AdhikariNational School of Tropical Medicine, Baylor College of Medicine.
Peter HotezNational School of Tropical Medicine, Baylor College of Medicine.
Maria Elena BottazziNational School of Tropical Medicine, Baylor College of Medicine.
Jeroen PolletNational School of Tropical Medicine, Baylor College of Medicine.

Funding

Institute for Integration of Medicine & Science: A Partnership to Improve HealthUM1TR004538 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ROBERT A CLARK, Kenneth M Hargreaves · 2023 to 2026
$22.3M
Preclinical Testing of Potential Next-generation Antischistosomal CompoundsR56AI180213 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ALWAN, SEVAN NAJM, CAMERON, MICHAEL DARIN · 2024 to 2024
$810k
NCATS NIH HHS UM1 TR004538NIAID NIH HHS R56 AI180213
6 · The paper itself

Abstract

Despite the global burden of helminth infections, no human vaccines have yet been licensed against these parasites. This study explored the development and evaluation of mRNA vaccine candidates targeting

Identifiers

PMID40909773
PMCPMC12408019

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.