Evidence map›Paper›PMID 40909783›Full record

ArticleResearch square2025

Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.

Ziyan Zhang, Cameron Keyser, Yaxin Li, Breandan J Rosolia, Morgan W Porch, Wen Zhang, Bin Su, Peng Jiang, R Suzanne Zukin, Jingqi Yan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Ziyan ZhangCenter for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.
Cameron KeyserCenter for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.
Yaxin LiDepartment of Chemistry, Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.
Breandan J RosoliaCenter for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.
Morgan W PorchDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
Wen ZhangDepartment of Psychiatry, Friedman Brain Institute, and Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Bin SuDepartment of Chemistry, Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.
Peng JiangCenter for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.
R Suzanne ZukinDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
Jingqi YanCenter for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115.ORCID https://orcid.org/0000-0002-7024-6423

Funding

Dysregulation of mTOR Signaling in Fragile X SyndromeR01MH092877 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ZUKIN, R. SUZANNE · 2011 to 2021
$4.3M
Targeting Androgen Receptor-HSP27 Signaling in GlioblastomaR15NS116766 · NINDS · CLEVELAND STATE UNIVERSITY · PI SU, BIN · 2021 to 2025
$891k
Quadrupole Time-of-Flight LC-MSS10OD030398 · OD · CLEVELAND CLINIC LERNER COM-CWRU · PI WILLARD, BELINDA BELLE · 2021 to 2021
$530k
Sensory experience-dependent autophagy induces synapse remodeling during critical periodR21NS118378 · NINDS · CLEVELAND STATE UNIVERSITY · PI YAN, JINGQI, ZUKIN, R. SUZANNE · 2020 to 2020
$462k
Role of autophagy in manganese-induced neurotoxicityR21ES028960 · NIEHS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ZHANG, ZIYAN · 2018 to 2019
$459k
NIEHS NIH HHS R21 ES028960NIH HHS S10 OD030398NIMH NIH HHS R01 MH092877NINDS NIH HHS R15 NS116766NINDS NIH HHS R21 NS118378
6 · The paper itself

Abstract

Dysregulated spine morphology is a common feature in pathology of many neurodevelopmental and neuropsychiatric disorders. Overabundant immature dendritic spines in the hippocampus are causally related to cognitive deficits of Fragile X syndrome (FXS), the most common form of heritable intellectual disability. Recent findings from us and others indicate autophagy plays important roles in synaptic stability and morphology, and autophagy is downregulated in FXS neurons. However, the mechanism remains unclear. In this study, we identified that activated autophagy degrades the eukaryotic initiation factor 4G1 (eIF4G1) and postsynaptic density protein-95 (PSD-95) in hippocampal neurons of

Indexed as

AutophagyCognition deficitsFragile X syndromePostsynaptic organization

Identifiers

PMID40909783
PMCPMC12408003

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.