Evidence map›Paper›PMID 40909797›Full record

ArticleResearch square2025

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Woochan Kim, Aaron K Wozniak, Nathaniel J Burkard, Michael L Freaney, Ailen Costamagna-Soto, Kelly O'Conor, Abolgasem Bakhoda, Seth M Eisenberg, Wenjing Zhao, Jeih-San Liow and 2 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    [2025
5 · Who and what money

Authors and funding

12 authors.

Woochan KimNational Institute on Alcohol Abuse and Alcoholism.
Aaron K WozniakNational Institute on Alcohol Abuse and Alcoholism.
Nathaniel J BurkardNational Institute on Alcohol Abuse and Alcoholism.
Michael L FreaneyNational Institute on Alcohol Abuse and Alcoholism.
Ailen Costamagna-SotoNational Institute on Alcohol Abuse and Alcoholism.
Kelly O'ConorNational Institute on Alcohol Abuse and Alcoholism.
Abolgasem BakhodaNational Institute on Alcohol Abuse and Alcoholism.
Seth M EisenbergNational Institute on Alcohol Abuse and Alcoholism.
Wenjing ZhaoNational Institute on Alcohol Abuse and Alcoholism.
Jeih-San LiowNational Institute of Mental Health.
Nora D VolkowNational Institute on Alcohol Abuse and Alcoholism.
Sung Won KimNational Institute on Alcohol Abuse and Alcoholism.ORCID 0000-0002-4647-4899

Funding

Neurobiology of Substance Abuse and AddictionZIAAA000550 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2025
$115.1M
Intramural NIH HHS ZIA AA000550
6 · The paper itself

Abstract

Background: Fentanyl is a potent synthetic opioid widely used for pain management and anesthesia, but the high prevalence of its misuse and its key contribution to overdose fatalities in the United States have made it a major drug of concern. Although fentanyl's onset, duration, and toxicity depend on its pharmacokinetics and specific tissue distribution, most studies have focused primarily on plasma concentrations, leaving its distribution in critical tissues largely unexplored (this knowledge gap limits our understanding of fentanyl's clinical effects, tissue accumulation, and the factors influencing its efficacy and safety). Here, we report the radiosynthesis of [ Results: [ Conclusions: We successfully developed and automated the radiosynthesis of [

Indexed as

Carbon-11FentanylPharmacokineticsPositron emission tomography

Identifiers

PMID40909797
PMCPMC12408011

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.