Evidence map›Paper›PMID 40909810›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable Proteins.

Chengyue Zhang, Iain R Konigsberg, Yixuan He, Jingzhou Zhang, Tinashe Chikowore, William B Feldman, Xiaowei Hu, Yi Ding, Bogdan Pasaniuc, Diana Chang and 17 more

2 registry-linked trialsAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00292552 completednot on this map

A Multicentre 3 Year Longitudinal Prospective Study to Identify Novel Endpoints and Compare These With Forced Expiratory Volume in 1 Second (FEV1) for Their Ability to Measure and Predict COPD Severity and Its Progression Over Time

TypeobservationalSponsorGlaxoSmithKlineRan2005 to 2010Enrolled2,747ConditionsPulmonary Disease, Chronic ObstructiveArmsNovel endpoint determination
NCT00608764 active not recruitingnot on this map

Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)

TypeobservationalSponsorBrigham and Women's HospitalRan2007 to 2028Enrolled10,718ConditionsPulmonary Disease, Chronic Obstructive, Emphysema, Bronchitis, Chronic
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Chengyue ZhangChanning Division of Network Medicine, Mass General Brigham, Boston, MA.ORCID 0009-0009-4537-8107
Iain R KonigsbergDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0001-7356-100X
Yixuan HeDepartment of Epidemiology School of Public Health, UTHealth Houston, Houston, TX.
Jingzhou ZhangPulmonary Center, Boston University School of Medicine, Boston, MA.
Tinashe ChikoworeChanning Division of Network Medicine, Mass General Brigham, Boston, MA.
William B FeldmanHarvard Medical School, Boston, MA.
Xiaowei HuDepartment of Public Health Genomics, University of Virginia, Charlottesville, VA.
Yi DingDepartment of Medicine, Dana-Farber Cancer Institute, Boston, MA.
Bogdan PasaniucCenter for Computational Biomedicine, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Diana ChangGenentech, South San Francisco, CA.
Qingwen ChenChanning Division of Network Medicine, Mass General Brigham, Boston, MA.
Jessica A Lasky-SuChanning Division of Network Medicine, Mass General Brigham, Boston, MA.
Julian HeckerChanning Division of Network Medicine, Mass General Brigham, Boston, MA.
Martin D TobinDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Jing ChenDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Sean KalraChanning Division of Network Medicine, Mass General Brigham, Boston, MA.
Katherine A PratteDivision of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO.
Hae Kyung ImDepartment of Human Genetics, Department of Medicine, University of Chicago, Chicago, IL.
Emily S WanSection on Pulmonary, Critical Care, Allergy, and Sleep Medicine, VA Boston Healthcare System, West Roxbury, MA.
Ani ManichaikulPublic Health Genomics Program, University of Virginia, Charlottesville, VA.
Edwin K SilvermanChanning Division of Network Medicine, Mass General Brigham, Boston, MA.
Russell P BowlerDepartment of Genetic Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, OH.
Leslie A LangeDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Victor E OrtegaDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Phoenix, AZ.
Alicia R MartinAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA.ORCID 0000-0003-0241-3522
Michael H ChoChanning Division of Network Medicine, Mass General Brigham, Boston, MA.ORCID 0000-0002-4907-1657
Matthew R MollChanning Division of Network Medicine, Mass General Brigham, Boston, MA.

Funding

Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI HERSH, CRAIG P · 2013 to 2025
$24.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7M
COPD Susceptibility, Heterogeneity, and Progression: Proteomics and GeneticsR01HL133135 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORITZ, ROBERT L, SILVERMAN, EDWIN K · 2017 to 2025
$7.2M
Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4qR01HL147148 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2019 to 2022
$3.5M
Identifying functional variants in COPD GWAS lociR01HL137927 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2017 to 2020
$3.5M
Identifying Protein-Protein Network Interactions between COPD Susceptibility GenesR01HL152728 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K, WEI, WENYI · 2021 to 2024
$3.2M
Clinical Implications, Genomics, and Transcriptions of Mucus Plugging in SmokersR01HL149861 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., DIAZ, ALEJANDRO · 2020 to 2023
$3.2M
Integrative genomic, transcriptomic and proteomic studies of pulmonary function and COPDR01HL153248 · NHLBI · UNIVERSITY OF VIRGINIA · PI CHO, MICHAEL H., MANICHAIKUL, ANI WANG · 2021 to 2024
$2.8M
Multi-omic Risk Prediction of Chronic Obstructive Pulmonary Disease in European- and African-Ancestry Populations_SupplementK08HL159318 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Matthew R Moll · 2022 to 2026
$918k
NHLBI NIH HHS K08 HL159318NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL133135NHLBI NIH HHS R01 HL135142NHLBI NIH HHS R01 HL137927NHLBI NIH HHS R01 HL147148NHLBI NIH HHS R01 HL149861NHLBI NIH HHS R01 HL152728NHLBI NIH HHS R01 HL153248NHLBI NIH HHS U01 HL089856
6 · The paper itself

Abstract

Objectives: To construct multi-trait polygenic scores (PRS) predicting chronic obstructive pulmonary disease (COPD) and exacerbations, validate their performance in diverse cohorts, and identify PRS-related proteins for potential therapeutic targeting. Design: Prospective cohort studies. Setting: Genetic Epidemiology of COPD (COPDGene; 2007-present), Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE; 2005-2008), Mass General Brigham Biobank (MGBB; 2010-present), All of Us (2016-present), and UK Biobank (UKB; 2006-present). Participants: 6,647 non-Hispanic White (NHW) and 2,466 African American (AA) participants from COPDGene; 1,858 participants from ECLIPSE; 118,566 from All of Us; 15,142 from MGBB with genetic data. 5,173 COPDGene and 5,012 UKB participants with proteomic data. Main outcome measures: COPD status (GOLD 2-4 vs. GOLD 0) and COPD exacerbation frequency. Results: PRSmix+, a multi-trait PRS framework, selected 7 traits for a composite PRS (PRS Conclusions: Multi-trait PRS improves prediction of COPD and exacerbation risk. Integration with proteomic data identifies druggable protein targets, offering a promising avenue for precision medicine in COPD management. Trial registration: COPDGene: NCT00608764; ECLIPSE: NCT00292552.

Identifiers

PMID40909810
PMCPMC12407601

What Socratic holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.