Evidence map›Paper›PMID 40909829›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Genetic and Cellular Architecture of Breast Cancer Risk in Multi-Ancestry Studies of 159,297 Cases and 212,102 Controls.

James L Li, Maria Zanti, Jacob Williams, Om Jahagirdar, Guochong Jia, Alistair Turcan, Qiang Hu, Jean-Tristan Brandenburg, Li Yan, Weang-Kee Ho and 35 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

James L LiDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA.
Maria ZantiBiostatistics Unit, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Jacob WilliamsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Om JahagirdarDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Guochong JiaDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Alistair TurcanRay and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Qiang HuDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Jean-Tristan BrandenburgSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Li YanDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Weang-Kee HoSchool of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor, Malaysia.
Jingmei LiGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore.
José Patricio MirandaDepartment of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Devika GodboleDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Julie-Alexia DiasDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Xiaomeng ZhangCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Leila DorlingCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Wenlong Carl ChenSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Nicholas BoddickerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Ying WangAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Alicia MartinAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Yan Dora ZhangDepartment of Statistics & Actuarial Science, School of Computing and Data Science, The University of Hong Kong, Hong Kong SAR, China.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Esther M JohnDepartments of Epidemiology & Population Health and of Medicine (Oncology), Stanford University School of Medicine, Stanford, CA, USA.
Gabriela Torres-MejiaInstituto Nacional de Salud Pública, Cuernavaca, Mexico.
Larry KushiUC Davis Genome Center, University of California, Davis, Davis, CA, USA.
Jeffrey WeitzelDivision of Precision Prevention, University of Kansas Comprehensive Cancer Center, Kansas City, KS, USA.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Luis Carvajal-CarmonaDepartment of Biochemistry and Molecular Medicine, School of Medicine, University of California at Davis, Davis, CA, USA.
Christopher HaimanDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Elad ZivDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Laura FejermanDepartment of Public Health Sciences, University of California Davis, Davis, CA, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Dezheng HuoDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA.
Douglas EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Nilanjan ChatterjeeDepartment of Biostatistics, Johns Hopkins University, Baltimore, MD, USA.
Peter KraftDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Montserrat Garcia-ClosasCancer Epidemiology and Prevention Research Unit, The Institute of Cancer Research and Imperial College London, London, UK.
Wendy S W WongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Kyriaki MichailidouBiostatistics Unit, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Qianqian ZhuDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Martin Jinye ZhangRay and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Diptavo DuttaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Thomas U AhearnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Haoyu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6423-0444

Funding

The Upstream Center: Income Interventions to Address the Fundamental Causes of Cancer InequitiesU54CA280811 · NCI · STANFORD UNIVERSITY · PI MELISSA L. BONDY · 2023 to 2026
$10.8M
University of California Minority Patient-Derived Xenograft (PDX) Development and Trial Center (UCaMP) to Reduce Cancer Health DisparitiesU54CA233306 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARVAJAL CARMONA, LUIS GUILLERMO, CHEN, MOON SHAO-CHUANG · 2018 to 2022
$6.8M
University of California and UT Southwestern D-PDTCU54CA283766 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Luis Guillermo Carvajal Carmona, Jonathan W Riess · 2023 to 2026
$5.9M
Medical Scientist National Research Service AwardT32GM150375 · NIGMS · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2023 to 2026
$5.5M
(PQ3) Addressing Cancer Treatment Disparities for Persons with HIVR01CA260689 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHIAO, ELIZABETH Y., SILVERBERG, MICHAEL J · 2021 to 2025
$4.0M
Understanding the biology of disparity-associated genomically stable gastric tumorsR56CA280636 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARVAJAL CARMONA, LUIS GUILLERMO · 2024 to 2025
$483k
NCI NIH HHS R01 CA260689NCI NIH HHS R56 CA280636NCI NIH HHS U54 CA233306NCI NIH HHS U54 CA280811NCI NIH HHS U54 CA283766NIGMS NIH HHS T32 GM150375
6 · The paper itself

Abstract

Breast cancer genome-wide association studies (GWAS) have identified over 200 independent genome-wide significant susceptibility markers. However, most studies have focused on one or two ancestral groups. We examined breast cancer genetic architecture using GWAS summary statistics from African (AFR), East Asian (EAS), European (EUR) and Hispanic/Latina (H/L) samples, totaling 159,297 cases and 212,102 controls, comprising the largest multi-ancestry study of breast cancer to date. The logit-scale heritability of breast cancer ranged from

Identifiers

PMID40909829
PMCPMC12407622

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.