Evidence map›Paper›PMID 40910039›Full record

SynthesisF1000Research2025

Review the role of oxygen-delivering nanobubbles in stroke therapy: A novel approach.

Hamzah Hamzah, Suryanti Suryanti, Idris Adewale Ahmed, Bambang Pujo Semedi, Abdullah Machin, Aditya Tri Hernowo

Abstract readSystematic Review
In one paragraph

Synthesis in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hamzah HamzahUniversitas Batam, Batam, Riau Islands, Indonesia.
Suryanti SuryantiLincoln University College, Petaling Jaya, Selangor, Malaysia.ORCID https://orcid.org/0009-0008-9978-2511
Idris Adewale AhmedLincoln University College, Petaling Jaya, Selangor, Malaysia.
Bambang Pujo SemediUniversitas Airlangga, Surabaya, East Java, Indonesia.
Abdullah MachinUniversitas Airlangga, Surabaya, East Java, Indonesia.
Aditya Tri HernowoInstitute Molekul Indonesia, 65151, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke remains a leading cause of mortality and long-term disability worldwide, necessitating innovative therapeutic strategies. The advent of nanotechnology, particularly oxygen-delivering nanobubbles (ODNBs), has introduced a promising avenue for enhancing stroke therapy. ODNBs have demonstrated the ability to improve oxygen delivery, enhance therapeutic efficacy, and provide diagnostic advantages through imaging contrast enhancement. However, challenges such as toxicity, off-target effects, and regulatory hurdles must be addressed before clinical translation. This review synthesizes the latest findings on ODNBs in stroke therapy, highlights their key benefits and challenges, and explores future applications, including gene therapy and brain tissue regeneration. By addressing these aspects, this review aims to provide a comprehensive understanding of the potential of ODNBs in revolutionizing stroke treatment.

Indexed as

MicrobubblesNanoparticlesOxygenStrokeAnimalsGenetic TherapyHumansOxygenischemicnanobublesoxygenrolestroke

Identifiers

PMID40910039
PMCPMC12405841

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.