Evidence map›Paper›PMID 40910209›Full record

ArticleAnti-cancer agents in medicinal chemistry2026

Evaluation of Anticancer Potential in Human Colorectal Carcinoma

Yaser E Alqurashi, Sami G Almalki, Ibrahim M Ibrahim, Aisha O Mohammed, Amal E Abd El Hady, Mehnaz Kamal, Faria Fatima, Danish Iqbal

Abstract read
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In one paragraph

Article in Anti-cancer agents in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yaser E AlqurashiDepartment of Biology, College of Science, Al-Zulfi, Majmaah University, Al-Majmaah, 11952, Saudi Arabia.
Sami G AlmalkiDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia.
Ibrahim M IbrahimDepartment of Clinical Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Aisha O MohammedDepartment of Biology, College of Science, Al-Zulfi, Majmaah University, Al-Majmaah, 11952, Saudi Arabia.
Amal E Abd El HadyDepartment of Biology, College of Science, Al-Zulfi, Majmaah University, Al-Majmaah, 11952, Saudi Arabia.
Mehnaz KamalDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Faria FatimaDepartment of Agriculture, Integral Institute of Agricultural Science and Technology (IIAST), Integral University, Lucknow-226026, India.
Danish IqbalDepartment of Health Information Management, College of Applied Medical Sciences, Buraydah Private Colleges, Buraydah 51418, Saudi Arabia.

Funding

deputyship for Research & Innovation, Ministry of Education in Saudi Arabia IFP-2022-41
6 · The paper itself

Abstract

introductionChemotherapy faces limitations such as toxicity and resistance, necessitating novel cancer treatments. Green-synthesized zinc oxide nanoparticles (ZnO-NPs) have attracted attention for their safety, biocompatibility, and therapeutic potential. This study investigates the anticancer efficacy of ZnO-NPs synthesized using the extracellular matrix of

methodsZnO-NPs were synthesized extracellularly using

resultsThe synthesized ZnO-NPs appeared pale white and exhibited a characteristic absorbance at 375 nm. SEM revealed spherical particles ranging from 35-150 nm. The ZnO-NPs showed strong anticancer activity with an IC DISCUSSION: ZnO-NPs exerted cytotoxic effects via ROS generation and mitochondrial dysfunction. These results underscore the nanoparticles' ability to induce apoptosis in cancer cells through oxidative stress pathways.

conclusionBiogenically synthesized ZnO-NPs from A. biplanus show promise as eco-friendly anticancer agents. Further in vivo studies are recommended to confirm their therapeutic potential.

Indexed as

Antineoplastic AgentsAspergillusColorectal NeoplasmsNanoparticlesZinc OxideAnimalsCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHCT116 CellsHumansMembrane Potential, MitochondrialMolecular StructureParticle SizeReactive Oxygen SpeciesAntineoplastic AgentsReactive Oxygen SpeciesZinc OxideAnticancerAspergillus biplanusMMPROStumour.Zinc-oxide nanoparticles

Identifiers

PMID40910209

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.