Evidence map›Paper›PMID 40910288›Full record

ReviewMini reviews in medicinal chemistry2025

Triterpenoid Compounds and their Derivatives: Emerging Pharmacological Agents for Arthritis Treatment.

Zihan Chen, Ka Fai Leong, Yuhan Xie, Alessandra Gianoncelli, Giovanni Ribaudo, Paolo Coghi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mini reviews in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zihan ChenSchool of Pharmacy, Macau University of Science and Technology, Macau SAR, 999078, China.
Ka Fai LeongFaculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, 999078, China.
Yuhan XieSchool of Pharmacy, Macau University of Science and Technology, Macau SAR, 999078, China.
Alessandra GianoncelliDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, 25123, Italy.
Giovanni RibaudoDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, 25123, Italy.
Paolo CoghiSchool of Pharmacy, Macau University of Science and Technology, Macau SAR, 999078, China.

Funding

FDCT, from Macau University of Science and Technology 0005-2023-RIA1
6 · The paper itself

Abstract

Arthritis has become a global public health issue due to its diverse risk factors and high prevalence. Therefore, there is a demand for more effective drugs to improve these situations. Triterpenoids have attracted the interest of researchers because of their broad spectrum of biological activities and pharmacological effects. The aim of this review is to provide an updated overview of the potential of triterpenoids and of their derivatives as therapeutic agents against Rheumatoid Arthritis (RA) and Osteoarthritis (OA), based on their anti-inflammatory and immunomodulatory properties. This review discusses the chemical and pharmacological properties of triterpenoids and their derivatives, focusing on the different mechanisms by which this class of compounds achieves therapeutic benefits in arthritis. The conclusions indicate that triterpenoids and their derivatives have a favorable potential therapeutic effect on arthritis.

Indexed as

Anti-Inflammatory AgentsArthritisArthritis, RheumatoidOsteoarthritisTriterpenesAnimalsHumansAnti-Inflammatory AgentsTriterpenesAIDS.inflammationnatural productsosteoarthritisrheumatoid arthritisTriterpenoids

Identifiers

PMID40910288

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.