Evidence mapPaperPMID 40911059Full record

ReviewZeitschrift fur Gerontologie und Geriatrie2025

[Age-associated changes of the immune system: immunosenescence and effects on vaccinations].

Birgit Weinberger, Peter Dovjak

Abstract readReviewEnglish Abstract
In one paragraph

Review in Zeitschrift fur Gerontologie und Geriatrie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Birgit WeinbergerInstitut für Biomedizinische Alternsforschung, Universität Innsbruck, Rennweg 10, 6020, Innsbruck, Österreich. Birgit.Weinberger@uibk.ac.at.
Peter DovjakSalzkammergut Klinikum Gmunden, Gmunden, Österreich.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complex changes of the innate and adaptive immune system occur in old age and contribute to the increased frequency and severity of infections in older adults. At the same time, chronic, subclinical inflammation occurs, which promotes age-related diseases. Age-associated changes in the immune system also influence the formation, growth and metastasis of malignant tumors. Furthermore, there are indications that the aging of the immune system contributes to the development of autoimmunity. Vaccinations are an important preventive measure for maintaining health and improving the quality of life, not only but especially in old age. The development of optimized and new vaccines for the older population has made great progress in recent years and decades; however, vaccination rates among older adults are well below target for all vaccinations.

Indexed as

AgingImmunosenescenceNeoplasmsVaccinationVaccinesAdaptive ImmunityAgedAged, 80 and overFemaleHumansImmunity, InnateMaleVaccinesAutoimmunityHematopoiesisInflammagingVaccination responseVaccines

Identifiers

PMID40911059
PMCPMC12454514

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.