Evidence map›Paper›PMID 40911069›Full record

ArticleJournal of neurology2025

Association between weekend recovery sleep and risk of incident dementia: a prospective cohort study in the UK Biobank.

Bo Zhao, Shaojiong Zhou, Jie Chang, Aonan Li, Chaofan Geng, Tao Wei, Yiwei Zhao, Peiyang Gao, Zhibin Wang, Yi Tang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bo Zhao *Department of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China.
Shaojiong Zhou *Department of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China.
Jie ChangNational Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.
Aonan LiDepartment of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China.
Chaofan GengDepartment of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China.
Tao WeiDepartment of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China.
Yiwei ZhaoDepartment of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China.
Peiyang GaoDepartment of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China.
Zhibin WangDepartment of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China. wangzhibinxw@163.com.
Yi TangDepartment of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China. tangyi@xwhosp.org.ORCID http://orcid.org/0000-0002-8052-065X

Funding

National Key Research and Development Program of China 2022YFC3602600National Natural Science Foundation of China 81970996National Natural Science Foundation of China 82220108009STI2030-Major Projects 2021ZD0201801
6 · The paper itself

Abstract

backgroundSleep deprivation has been linked to higher dementia risk, but the role of weekend recovery sleep (WRS) in mitigating this risk remains unclear. This study aims to evaluate the association between WRS and dementia risk.

methodsThis prospective cohort study followed 88,592 dementia-free adults aged 40-79 years from the UK Biobank, using wrist accelerometers to measure average weekday and weekend sleep durations. Incident dementia (all-cause dementia, Alzheimer's disease [AD], vascular dementia [VaD], and nonspecific dementia) was determined using medical records. Associations were estimated using Cox proportional hazards models and restricted cubic splines (RCS).

resultsAmong 88,592 participants (mean [SD] age, 61.9 [7.9] years), 735 (0.83%) developed dementia, including 308 (0.35%) cases of AD, 137 (0.15%) cases of VaD, and 319 (0.36%) cases of nonspecific dementia. RCS analyses revealed optimal weekday sleep durations associated with the lowest dementia risk: 8.38 h (HR, 0.73; 95% CI 0.64-0.84) for all-cause dementia, 8.33 h (HR, 0.72; 95% CI 0.58-0.89) for AD, and 9.07 h (HR, 0.59; 95% CI 0.40-0.88) for VaD. In the suboptimal sleep group (weekday sleep less than optimal duration), longer WRS was associated with reduced risks of all-cause dementia (HR, 0.801; 95% CI 0.717-0.893) and VaD (HR, 0.747; 95% CI 0.612-0.91). However, in the prolonged sleep group (weekday sleep exceeding optimal duration), longer WRS was linked to an increased nonspecific dementia risk (HR, 1.291; 95% CI 1.087-1.533).

conclusionAdequate WRS can reduce dementia risk, particularly for VaD, after insufficient weekday sleep, highlighting the importance of appropriate WRS for cognitive health.

Indexed as

DementiaSleepSleep DeprivationAdultAgedBiological Specimen BanksCohort StudiesFemaleHumansIncidenceMaleMiddle AgedProspective StudiesRisk FactorsTime FactorsUK BiobankBrain structureCognitive functionDementiaSleepVascular dementia

Identifiers

PMID40911069

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.