ReviewMolecular biomedicine2025
Acute kidney injury: pathogenesis and therapeutic interventions.
Review in Molecular biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Beyond traditional biomarkers: do serum cystatin C and urinary cystatin B improve diagnostic precision in feline and canine renal disease? A systematic review and meta-analysis.Frontiers in veterinary science · 2026Pooled it
- Acute kidney injury in critically ill children: Incidence, severity, and clinical outcomes from a quaternary pediatric intensive care unit in an upper-middle-income country.Pediatric nephrology (Berlin, Germany) · 2026Article
- Echinacoside Alleviates Cisplatin-Induced Acute Kidney Injury by Regulating Bap1 to Inhibit Ferroptosis.Biomedicines · 2026Article
- Kaempferol conjugated selenium nanoparticles mitigate kidney injury from rhabdomyolysis through antioxidant and anti-inflammatory actions via Nrf2/NF-κb pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- A rare intravenous paraquat exposure presenting with novel and atypical severe clinical manifestations.Indian journal of pharmacology · 2026Article
- Integrating Bulk and Single-Cell RNA Sequencing Identifies and Validates Lactylation-Related Signatures in Acute Kidney Injury.Biomedicines · 2026Article
- Selenoprotein H targets MTCH2 to regulate MFN2-dependent mitochondrial quality control to alleviate acute kidney injury.Journal of advanced research · 2026Article
- Transcriptomics reveal dysregulated genes during folic acid-induced acute injury and fibrosis in kidney and their attenuation by antioxidantAmerican journal of physiology. Cell physiology · 2026Article
- Gut microbiota dysbiosis in intensive care unit patients with acute kidney injury: insights from 16S sequencing and mediation analysis.BMC nephrology · 2026Article
- The E3 ligase TRIM29 drives renal ischemia-reperfusion injury by targeting DUSP10 for proteasomal degradation.Cell death & disease · 2026Article
- Severe adenovirus-associated pneumonia complicated by biopsy-evaluated acute kidney injury in an immunocompetent adult: a case report.BMC nephrology · 2026Article
- Association of systemic inflammation response index with postoperative clinical outcomes among operated patients with aortic dissection: a systematic review with meta-analysis.Journal of thoracic disease · 2026Article
- Stress-Dependent NF-κB Signaling in Acute Kidney Injury: Linking Inflammation, Autophagy, and Apoptosis.International journal of molecular sciences · 2026Review
- Exploratory Analysis of Early Renal Function Changes After Transcatheter Aortic Valve Implantation (TAVI): Limited Predictive Value Beyond Baseline Renal Function.Journal of clinical medicine · 2026Article
- Article
- Integrative Network Pharmacology and Molecular Docking Analysis Uncovers Multi-Target Mechanisms of Alpha-Mangostin Against Acute Kidney Injury.Foods (Basel, Switzerland) · 2026Article
- Renal-targeted tFNA-TPP nanoagonist treats acute kidney injury by amplifying mitophagy.Materials today. Bio · 2026Article
- Renal Resistive Index on Admission Predicts and Mediates Acute Kidney Injury: A Prospective Observational Study from a Greek Intensive Care Unit.Journal of clinical medicine · 2026Article
- Therapeutic rewiring of ceRNA networks: a computational pipeline for drug repurposing in acute kidney injury via circRNA-miRNA-mRNA axis disruption.Human genomics · 2026Review
- Mitophagy and Cellular Homeostasis in Kidney Diseases: Mechanisms and Potential Therapeutics.International journal of biological sciences · 2026Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Acute kidney injury (AKI) is a prevalent clinical condition that is associated with unacceptably high morbidity and mortality, as well as the development of chronic kidney disease (CKD). The pathogenesis of AKI is highly complex and heterogeneous, primarily attributed to metabolic disturbances arising from the disease itself and the administration of medications related to treatment. In recent years, AKI in cancer patients is highly concerned. The emergence of AKI caused injuries and dysfunction of remote organs but also enhanced the health-care costs. It's essential for early recognition of AKI by biomarker or prediction models and further, take a timely intervention. This review aims to provide the pathophysiology of AKI covering the intricate mechanisms underpinning AKI in the dynamic context of the clinical setting, the tailored role of inflammation and ischemia, and the cellular and molecular crosstalk pathways involved. These events closely related to patients at high risk of AKI and underscore the characteristics that may make these patients more susceptible to injury. Furthermore, the diagnosis of AKI relies on clinical criteria, biomarkers, and imaging, but it should be distinguished from CKD. Finally, the review offers the therapeutic intervention in clinical practice and preclinical or clinical trials, focusing on the improvement of conventional therapy and advanced novel treatment strategies. Simultaneously, the challenge and future direction on early identifying renal impairment and performing renoprotection are also discussed, further supporting the novel discipline including onco-nephrology. The development of effective interventions that reduce nephrotoxicity is highly contingent upon a thorough understanding of the molecular pathophysiology of AKI.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.