ArticleACS nano2025
ZnCe-LDO Nanozyme-Based Multifunctional Hydrogel Promotes Bone Regeneration by Inflammatory Macrophage Reprogramming and Piezo1 Activation.
Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Artificial intelligence-guided nanozyme engineering for chronic wound healing: from rational design to precision therapeutics.Bioactive materials · 2027Review
- Bone defect repair materials after bone tumour resection: from structural substitutes to biofunctionalized synergistic therapy.Annals of medicine · 2026Review
- Near-Infrared Responsive Property and Nanozyme Effect-Mediated 3D-Printed Gradient Bioactive Scaffold for Intelligent Immunomodulation in Regeneration of Large Segmental Bone Defects.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Advances in GelMA Hydrogel-Enabled Angiogenic-Osteogenic Coupling: From Structural Programming to Exogenous Cue Synergy.Journal of functional biomaterials · 2026Review
- 3D HucMSCs derived extracellular vesicles enhanced therapeutic efficacy in treating intrauterine adhesions via BECN1 delivery.Materials today. Bio · 2026Article
- High-performance hydrogels in orthopedics: Structural design, performance tuning, and clinical potential.Materials today. Bio · 2026Review
- Yoda molecules agonize PIEZO2.bioRxiv : the preprint server for biology · 2026Article
- The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibitor.Apoptosis : an international journal on programmed cell death · 2026Review
- Hydrogel-Based Immunomodulatory Strategies for Infected Bone Defects Regeneration: Remodeling the Osteoimmune Microenvironment and Future Perspectives.International journal of nanomedicine · 2026Review
- Multi-cell-component cartilage organoids simulate intercellular microstress, hypoxic microenvironment, and chondrocyte-endothelial crosstalkFrontiers in bioengineering and biotechnology · 2026Article
- Nanozymes for Bone Regeneration: Mechanistic Insights into Immune and Metabolic Microenvironment Modulation.International journal of nanomedicine · 2026Review
- Tri-Functional MgTA@MnOInternational journal of nanomedicine · 2026Article
- Nanohydrogels for Diabetic Wound Healing: Mechanisms, Applications, and Future Perspectives.International journal of nanomedicine · 2026Review
- Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolonged or excessive inflammation may lead to impaired vascularization and bone regeneration, hindering the normal repair process of bone tissue. Although the regulation of inflammation is crucial for promoting a conducive microenvironment for bone regeneration, individual anti-inflammatory interventions frequently are inadequate in facilitating effective bone repair. Here, a multifunctional hydrogel (GelMA-ZC-Yoda1) with multifaceted therapeutic strategy was designed by integrating Zinc/Cerium-layered double oxide nanozyme (ZnCe-LDO, with catalase-like activity) and Yoda1 (an activator of the mechanically sensitive Piezo1 ion channel) into photocurable GelMA hydrogel. The ZnCe-LDO nanozyme in the hydrogel promoted M2 macrophage polarization by reprogramming inflammatory macrophages, establishing a favorable microenvironment, while the sustained release of zinc and cerium ions facilitated osteo/angiogenesis. Additionally, the Yoda1 released from the hydrogel chemically simulated a mechanical signal to activate the Piezo1 channel, regulating osteo/angiogenesis via the Piezo1/YAP1 signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.