Evidence map›Paper›PMID 40911305›Full record

ArticleJAMA network open2025

Alzheimer Disease Biomarkers and Subjective Cognitive Decline Among Hispanic and/or Latino Adults.

Freddie Márquez, Wassim Tarraf, Kevin Gonzalez, Deisha F Valencia, Ariana M Stickel, Natasha Z Anita, Daniela Sotres-Alvarez, Bonnie E Levin, Michael A Yassa, Haibo Zhou and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA network open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Freddie MárquezDepartment of Neurosciences, University of California, San Diego, La Jolla.
Wassim TarrafInstitute of Gerontology and Department of Healthcare Sciences, Wayne State University, Detroit, Michigan.
Kevin GonzalezDepartment of Neurosciences, University of California, San Diego, La Jolla.
Deisha F ValenciaDepartment of Neurosciences, University of California, San Diego, La Jolla.
Ariana M StickelDepartment of Psychology, San Diego State University, San Diego, California.
Natasha Z AnitaDepartment of Neurosciences, University of California, San Diego, La Jolla.
Daniela Sotres-AlvarezDepartment of Biostatistics, University of North Carolina at Chapel Hill.
Bonnie E LevinDepartment of Neurology, University of Miami, Miami, Florida.
Michael A YassaDepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California, Irvine.
Haibo ZhouDepartment of Biostatistics, University of North Carolina at Chapel Hill.
Martha DaviglusInstitute for Minority Health Research, College of Medicine, University of Illinois at Chicago.
Amber PirzadaInstitute for Minority Health Research, College of Medicine, University of Illinois at Chicago.
Zachary T GoodmanDepartment of Psychology, University of Miami, Miami, Florida.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.
Linda C GalloDepartment of Psychology, San Diego State University, San Diego, California.
Hector M GonzálezDepartment of Neurosciences, University of California, San Diego, La Jolla.

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Enhanced Machine Learning Tools for Complex Data Evaluation and Integration in Advancing Health OutcomesR01HL173044 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Baiming Zou, Fei Zou · 2025 to 2026
$1.3M
NHLBI NIH HHS R01 HL173044NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

Importance: Subjective cognitive decline (SCD) may be an early indicator of Alzheimer disease and related dementias (ADRD), yet its association with plasma biomarkers remains unclear among middle-aged and older adults (aged 50-86 years). Objective: To examine associations between plasma biomarkers of amyloid, tau, neuroaxonal damage, and glial activation with SCD in a heterogeneous cohort of Hispanic and/or Latino adults. Design, Setting, and Participants: This cross-sectional study used survey-weighted data from the Study of Latinos-Investigation of Neurocognitive Aging, an ancillary study of the Hispanic Community Health Study/Study of Latinos. Participants were aged 50 to 86 years and resided in 4 major US cities. Data were collected from 2016 to 2018 and analyzed between December 2024 and June 2025. Exposure: Plasma biomarkers included amyloid-beta (Aβ42/40), phosphorylated tau-181 (ptau-181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP), quantified using Simoa (Quanterix HD-X) and log-transformed (ln) to reduce skewness. Main Outcomes and Measures: SCD was assessed using the short-form Everyday Cognition Scale (ECog-12), evaluating global-, executive-, and memory-related SCD, and a single-item cognitive concerns question. Survey-weighted linear and logistic regression models tested associations between biomarkers and SCD, adjusting for demographic, cardiovascular, kidney, and APOE genotype covariates. Results: Among 5712 adults (mean [SD] age, 63.47 (8.15) years; unweighted 3663 [53.92%] female), higher ln(ptau-181) was associated with ECog-12 memory (unstandardized β = 0.088; 95% CI, 0.005-0.170). Higher ln(NfL) levels were associated with greater ECog-12 global (unstandardized β = 0.169; 95% CI, 0.074-0.265), executive (unstandardized β = 0.182; 95% CI, 0.087-0.277), and memory (unstandardized β = 0.156; 95% CI, 0.065-0.248) domains. Higher ln(GFAP) levels were associated with greater ECog-12 global (unstandardized β = 0.109; 95% CI, 0.019-0.198) and executive (unstandardized β = 0.121; 95% CI, 0.031-0.211) domains. Ln(Aβ42/40) was not associated with SCD domains. Cognitive concerns significantly modified the associations between ln(NfL) and ECog-12 domains, with more pronounced associations among those reporting cognitive concerns. No biomarkers were associated with the single-item cognitive concerns score. Conclusions and Relevance: In this study of middle-aged and older Hispanic and/or Latino adults, plasma biomarkers of p-tau181, NfL, and GFAP, but not Aβ42/40, were associated with greater SCD. These findings underscore their potential utility in early ADRD detection strategies.

Indexed as

Alzheimer DiseaseCognitive DysfunctionHispanic or LatinoAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersCross-Sectional StudiesFemaleGlial Fibrillary Acidic ProteinHumansMaleMiddle AgedNeurofilament Proteinstau ProteinsUnited StatesAmyloid beta-PeptidesBiomarkersGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinstau Proteins

Identifiers

PMID40911305
PMCPMC12413646

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.