Evidence map›Paper›PMID 40911682›Full record

ArticleScience advances2025

HIV-1 manipulates CD96 on CD4

Sandra Dehn, Rabea Burkhard, Johanna Leyens, Tabea Kaiser, Simone Brandimarte, Dinah Heiligensetzer, Herwig Koppensteiner, Baubak Bajoghli, Stephan Hailfinger, Karin Schilbach and 1 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Persistent CD8Frontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sandra DehnInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.ORCID 0000-0001-5727-5396
Rabea BurkhardInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
Johanna LeyensInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.ORCID 0009-0009-1689-4751
Tabea KaiserInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.ORCID 0009-0007-4132-3104
Simone BrandimarteInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
Dinah HeiligensetzerInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.ORCID 0009-0003-2158-4981
Herwig KoppensteinerInstitute of Virology, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Baubak BajoghliDepartment of Oncology, Hematology, Immunology and Rheumatology, University Hospital Tübingen, Tübingen, Germany.ORCID 0000-0002-7368-7523
Stephan HailfingerDepartment of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.
Karin SchilbachDepartment of Pediatric Hematology and Oncology, University Children's Hospital Tübingen, Tübingen, Germany.
Michael SchindlerInstitute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.ORCID 0000-0001-8989-5813

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV-1 evades immune responses by modulating plasma membrane receptors. Using a flow cytometry-based screening, we profiled 332 surface receptors on HIV-1-infected primary CD4

Indexed as

Antigens, CDCD4-Positive T-LymphocytesHIV-1HIV InfectionsImmune EvasionBone Marrow Stromal Antigen 2Human Immunodeficiency Virus ProteinsHumansInterferon-gammaTh1 CellsViral Regulatory and Accessory ProteinsAntigens, CDBone Marrow Stromal Antigen 2BST2 protein, humanHuman Immunodeficiency Virus ProteinsInterferon-gammaViral Regulatory and Accessory Proteins

Identifiers

PMID40911682
PMCPMC12412668

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.