ArticleMolecular cell2025
For "U" the bell tolls: Pseudouridine evades TLR detection.
Article in Molecular cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
Funding
Abstract
TLRs detect pathogen-derived uridine but not endogenous pseudouridine, which promotes host defense without autoimmunity. This principle is critical for the safe design of mRNA-based therapeutics, but the underlying mechanisms driving differential innate immune activation were unknown. In a recent issue of Cell, Bérouti et al.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.