Evidence map›Paper›PMID 40912323›Full record

ArticleJournal of affective disorders2026

Neonatal striatal volume is associated with infant anhedonia.

Melissa Nevarez-Brewster, Catherine H Demers, Jessica L Irwin, Laura M Glynn, Martin A Styner, Mercedes Hoeflich Haase, M Camille Hoffman, Diego A Pizzagalli, Benjamin L Hankin, Elysia Poggi Davis

Abstract read
In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Melissa Nevarez-BrewsterUniversity of Denver, Department of Psychology, United States of America. Electronic address: melissa.nevarezbrewster@du.edu.
Catherine H DemersUniversity of Denver, Department of Psychology, United States of America; University of Colorado Anschutz Medical Campus, Department of Psychiatry, United States of America.
Jessica L IrwinChapman University, Department of Psychology, United States of America.
Laura M GlynnChapman University, Department of Psychology, United States of America.
Martin A StynerUniversity of North Carolina - Chapel Hill, Department of Psychiatry, United States of America; University of North Carolina - Chapel Hill, Department of Computer Science, United States of America.
Mercedes Hoeflich HaaseUniversity of North Carolina - Chapel Hill, Department of Computer Science, United States of America.
M Camille HoffmanUniversity of Colorado Anschutz Medical Campus, Department of Psychiatry, United States of America; University of Colorado Anschutz Medical Campus, Department of Obstetrics & Gynecology, United States of America.
Diego A PizzagalliUniveristy of California, Irvine, Psychiatry & Human Behavior School of Medicine, United States of America; University of California, Irvine, Department of Neurobiology and Behavior, United States of America.
Benjamin L HankinUniversity of Illinois at Urbana-Champaign, Department of Psychology, United States of America.
Elysia Poggi DavisUniversity of Denver, Department of Psychology, United States of America; University of California, Irvine, Department of Pediatrics, United States of America. Electronic address: elysia.davis@du.edu.

Funding

Structural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMAN, CURT ALAN · 2013 to 2023
$25.4M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark D Shen · 2020 to 2026
$9.7M
Neuroimaging Studies of Reward Processing in DepressionR37MH068376 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI Diego A Pizzagalli · 2016 to 2026
$7.4M
Reducing Fetal Exposure to Maternal Depression to Improve Infant Risk MechanismsR01MH109662 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, HANKIN, BENJAMIN L · 2017 to 2021
$4.0M
Reducing maternal prenatal depression to improve child cardiovascular healthR01HL155744 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DAVIS, ELYSIA POGGI, DOOM, JENALEE RAE · 2021 to 2025
$3.6M
The Colorado Building Interdisciplinary Research Careers in Women's Health ProgramK12AR084226 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI JUDITH G. REGENSTEINER, Nanette F. Santoro · 2023 to 2026
$2.5M
Prenatal maternal depression exposure and infant neurocircuitry developmentF32MH125572 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI DEMERS, CATHERINE · 2021 to 2021
$66k
NHLBI NIH HHS R01 HL155744NIAMS NIH HHS K12 AR084226NICHD NIH HHS P50 HD103573NIMH NIH HHS F32 MH125572NIMH NIH HHS P50 MH096889NIMH NIH HHS R01 MH109662NIMH NIH HHS R37 MH068376Wellcome Trust
6 · The paper itself

Abstract

Anhedonia is increasingly recognized as a transdiagnostic risk factor for psychopathology. New evidence demonstrates that anhedonia is present in infancy and early childhood. Structural variability in striatal regions involved in reward processing and pleasure seeking is concurrently linked to anhedonia, yet few studies have examined whether striatal differences presage anhedonia, and none have examined prospective associations before middle childhood. The present study examined whether neuroanatomical markers that confer risk for anhedonia can be detected as early as the neonatal period. Specifically, we tested whether the volume of striatal regions in neonates predicted the emergence of infant anhedonic behaviors at six months of age. Our sample included 89 neonates (47 females, 42 males) from the Care Project - a longitudinal cohort study of pregnant individuals and their children. Neonatal striatal volume (nucleus accumbens, putamen, and caudate) was assessed using structural magnetic resonance imaging (MRI; M

Indexed as

AnhedoniaCorpus StriatumNucleus AccumbensCaudate NucleusFemaleHumansInfantInfant, NewbornLongitudinal StudiesMagnetic Resonance ImagingMaleOrgan SizePutamenRewardAnhedonic behaviorsInfancyLongitudinalNeonatal neuroimaging

Identifiers

PMID40912323
PMCPMC12747224

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.