Evidence map›Paper›PMID 40912667›Full record

ArticleBone2025

Plasma proteomic markers of pain and emotional dysfunction in fibrous dysplasia/McCune-Albright syndrome.

Camryn Berry, Evan E Hsu, Courtney LeSon, Kailey E Brodeur, Edin Randall, Julie Shulman, Catherine Stewart, Shealyn O'Donnell, Boyu Ren, Ingrid A Holm and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Camryn BerryDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Evan E HsuDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Courtney LeSonDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kailey E BrodeurDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Edin RandallDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Julie ShulmanDepartment of Physical Therapy and Occupational Therapy, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Catherine StewartDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Shealyn O'DonnellDepartment of Physical Therapy and Occupational Therapy, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Boyu RenDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Ingrid A HolmDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Alison M BoyceMetabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Zachary S PeacockDepartment of Oral & Maxillofacial Surgery, Harvard School of Dental Medicine, Division of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, USA.
Navil SethnaDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Michael MannstadtEndocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Pui Y LeeDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Jaymin UpadhyayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA. Electronic address: jaymin.upadhyay@childrens.harvard.edu.

Funding

Dissecting Central Mechanisms of Hypoalgesia in SchizophreniaR21MH122967 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI SHINN, ANN KYUNGAH, UPADHYAY, JAYMIN A · 2020 to 2020
$490k
NIMH NIH HHS R21 MH122967
6 · The paper itself

Abstract

Pain in Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) remains poorly understood and inadequately managed due to uncertainties regarding clinical or biological drivers. This cross-sectional pilot study aimed to use plasma proteomics to identify markers that inform on molecular pathways associated with pain and emotional symptoms in FD/MAS. Seventeen individuals (15 females, 2 males), aged 16 to 63 years, with confirmed diagnoses of monostotic FD, polyostotic FD, or MAS participated in a single study visit conducted at Boston Children's Hospital and Massachusetts General Brigham. During the visit, participants completed validated questionnaires assessing neuropathic pain characteristics, pain interference, anxiety symptoms, depression symptoms, and perceived stress, and provided plasma samples. These samples were analyzed for 57 proteins using Olink proximity extension assay. Associations between protein concentrations and symptom scores were evaluated using Spearman's correlations with false discovery rate correction (|r| > 0.5, p < 0.05). After FDR correction, the concentrations of seven proteins (TNF-α, LTA, CCL19, CSF2, CCL2, CCL4, CCL7) significantly correlated with pain interference, HADS-depression scores, or perceived stress. Four protein concentrations (TNF-α, CCL19, CSF2, CCL7) significantly correlated with multiple clinical measures. This pilot study identified several pain-associated proteins in individuals with FD/MAS, suggesting that proteomic profiling may be a promising approach for discovering pain biomarkers. Larger, longitudinal studies are needed to validate these results and investigate whether targeting immune pathways can alleviate pain and improve emotional health in FD/MAS.

Indexed as

BiomarkersFibrous Dysplasia, PolyostoticPainProteomicsAdolescentAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedPilot ProjectsYoung AdultBiomarkersChronic painFibrous dysplasiaInflammatory biomarkersMcCune-Albright syndromePlasma proteomics

Identifiers

PMID40912667
PMCPMC12422411

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.