ArticleJACC. Case reports2025
A Rare Intra-Atrial Cyst of Vascular Origin: Genetic Insights From a Case.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundIntra-atrial cysts are rare and often mistaken for neoplastic lesions. Vascular-origin cysts are even more uncommon. Limited genetic data hamper understanding of their pathogenesis and management. CASE SUMMARY: A 64-year-old man was referred for evaluation of an incidentally detected right atrial mass. Echocardiography suggested a hemorrhagic cyst. Surgical excision and histopathology confirmed a vascular malformation, with CD34 and smooth muscle actin positivity, elastic fibers demonstrated on special staining. Genetic testing revealed a pathogenic TSC2 mutation. The patient underwent successful mass resection and tricuspid annuloplasty with uneventful recovery. DISCUSSION: This case highlights a rare intra-atrial blood cyst associated with TSC2 mutation, suggesting a genetic basis for vascular malformations. TSC2 screening may help differentiate benign from malignant cardiac lesions, especially those with hemorrhagic features. In selected cases, image-guided aspiration could be a less-invasive alternative to surgery. TAKE-HOME MESSAGE: TSC2 genetic testing may improve diagnosis and guide treatment strategies for atypical cardiac vascular lesions.
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