Elevated Lipoprotein(a) Levels and Massive Ruptured Root and Ascending Aortic Aneurysm.

Shubh K Patel, Syed M Ali Hassan, Nitish K Dhingra, Raj Verma, Subodh Verma

Abstract readCase Reports

In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shubh K PatelTemerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Syed M Ali HassanTemerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiac Surgery, St Michael's Hospital of Unity Health Toronto, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Nitish K DhingraDivision of Cardiac Surgery, St Michael's Hospital of Unity Health Toronto, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Raj VermaSchool of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.

Subodh VermaTemerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiac Surgery, St Michael's Hospital of Unity Health Toronto, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address: subodh.verma@unityhealth.to.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRupture of a root and ascending aortic aneurysm is a rare, life-threatening condition requiring prompt recognition and surgical intervention. Elevated lipoprotein(a) levels have been implicated in vascular pathology but are less studied in thoracic aneurysms. CASE SUMMARY: A 61-year-old man who presented with severe dyspnea and chest tightness was found to have a 7.3-cm ruptured root and ascending aortic aneurysm with elevated lipoprotein(a) (233 nmol/L). He underwent emergency surgery, including a mechanical Bentall procedure, ascending aortic and hemiarch replacement, and bilateral pericardiectomy. At follow-up, he was clinically stable with a well-seated valve conduit and no complications. DISCUSSION: This case suggests a potential association between elevated lipoprotein(a) and thoracic aortic aneurysm rupture, possibly linked its proatherogenic and proinflammatory properties in vascular pathology. Further investigations are needed to clarify its role in aneurysm risk stratification. TAKE-HOME MESSAGES: Elevated lipoprotein(a) may contribute to thoracic aortic aneurysm progression. Its role in risk stratification warrants further investigation.

Indexed as

ascending aortic aneurysmlipoprotein(a)mechanical Bentall procedure

Identifiers

PMID40912852

DOI10.1016/j.jaccas.2025.104921

PMCPMC12426640

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LicenceCC BY

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