Evidence map›Paper›PMID 40912883›Full record

ArticleHeart rhythm2025

Advances that position intracellular calcium dysregulation as an emerging therapeutic target in heart disease.

Francisco J Alvarado, Erick B Ríos Pérez

Abstract read
In one paragraph

Article in Heart rhythm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Francisco J AlvaradoDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin; Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin. Electronic address: falvarad@medicine.wisc.edu.
Erick B Ríos PérezDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin; Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.

Funding

Partial and Controlled Depletion of SR Calcium by RyR Agonists Prevents Calcium-dependent ArrhythmiasR01HL167195 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado, Hector H Valdivia · 2023 to 2026
$2.4M
Mechanisms of calcium-induced arrhythmias in arrhythmogenic right ventricular cardiomyopathyR01HL161070 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado · 2022 to 2026
$1.9M
NHLBI NIH HHS R01 HL161070NHLBI NIH HHS R01 HL167195
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40912883
PMCPMC12416737

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.