ArticleOpen heart2025
Role of stroke volume in patients presenting with uncomplicated anterior STEMI.
Article in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundStroke volume is an established echocardiographic marker but has not been widely studied in patients with ST-segment elevation myocardial infarction (STEMI). We aimed to evaluate stroke volume in a cohort of uncomplicated anterior STEMI and to assess its prognostic role in those with severe left ventricle (LV) systolic dysfunction. METHODS AND
resultsThis is a single-centre retrospective analysis of consecutive patients presenting with anterior STEMI who underwent uncomplicated primary percutaneous coronary intervention. Stroke volume was measured using echocardiography within in-hospital admission. The primary endpoint was cardiovascular mortality. Of 3592 patients with STEMI, 616 were included. The mean age was 65±14 years (76% males). The average left ventricular ejection fraction (LVEF) and stroke volume were 39±11% and 62±18 mL, respectively. There was a modest relationship between stroke volume and LVEF (r=0.33, p<0.001), which was not maintained in patients with severe LV dysfunction (r=0.11, p=0.19). On multivariate analysis, stroke volume was associated with cardiovascular death at 12 months (HR 0.92, 95% CI 0.86 to 0.98, p=0.015) in patients with severe LV systolic dysfunction. Receiver operating characteristic analysis demonstrated an area under the curve of 0.80 (95% CI 0.70 to 0.91, p<0.001) in this group with negative predictive value of 99% for cardiovascular mortality.
conclusionsStroke volume is a readily and useful echocardiographic marker to assess prognosis in patients with anterior STEMI and severe LV systolic dysfunction. It identifies with a high degree of certainty those patients who are likely to survive despite their severe LV systolic dysfunction.
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