ArticleCell death and differentiation2026
PRMT5 encourages cell migration and metastasis of tongue squamous cell carcinoma through methylating ΔNp63α.
Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Protein modification systems as cancer biomarkers and therapeutic targets.Precision clinical medicine · 2026Review
- Sex determining region Y box protein 2 (SOX2) expression, alteration, regulation and its diagnostics, prognostics and therapeutics in lung cancer.Discover oncology · 2026Article
- Multi-omics biomarkers in female fertility: from oocyte quality to endometrial receptivity and clinical translation.Biomarker research · 2026Review
- Enhancing CD8Biomolecules · 2025Article
- Transcriptome and metabolome analyses revealed the main profiles contributing the mild aroma characteristics ofFrontiers in plant science · 2025Article
- Salt sensitivity potentiates high-salt diet-induced intestinal barrier disruption and gut microbiome dysbiosis in rats.Frontiers in microbiology · 2025Article
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Authors and funding
17 authors.
Funding
Abstract
Tongue squamous cell carcinoma (TSCC) is a common oral malignancy prone to metastasis, whose underlying mechanism remains obscure. Here, we report the oncogenic roles of protein arginine methyltransferase 5 (PRMT5) in TSCC via inhibiting transcription factor ΔNp63α. We found that PRMT5 physically interacts with ΔNp63α, resulting in impairment of ΔNp63α-mediated transcriptional regulation. Further investigation revealed that PRMT5 is significantly upregulated in late stages of TSCC and correlated to poor prognosis. On the other hand, inhibition on ΔNp63α contributes to PRMT5-induced migration and metastasis of TSCC cells. Mechanistically, PRMT5 mediates methylation of ΔNp63α at Arg561, which facilitates CDK1-mediated phosphorylation of ΔNp63α and results in weakened DNA binding of this transcription factor. Consequently, ΔNp63α-mediated suppression on cell migration is attenuated in TSCC. Inhibition of PRMT5 efficiently restrain metastasis of TSCC cells in vivo. Our study is helpful to illuminate the molecular mechanism of TSCC metastasis and to provide a new therapeutic strategy for this malignancy.
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