Evidence map›Paper›PMID 40913130›Full record

ArticleEuropean journal of applied physiology2026

Metabolic cost of external work: a novel CPET parameter optimises characterisation of exercise performance in obese individuals.

Jennifer J Rayner, Rebecca R Chamley, Robert Barker Davies, Oliver O'Sullivan, Peter Ladlow, Alex N Bennett, Edward D Nicol, Oliver J Rider, David A Holdsworth

Abstract read
In one paragraph

Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jennifer J RaynerDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3519-5480
Rebecca R ChamleyDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.
Robert Barker DaviesAcademic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, LE21 5QW, UK.
Oliver O'SullivanAcademic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, LE21 5QW, UK.
Peter LadlowAcademic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, LE21 5QW, UK.
Alex N BennettAcademic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, LE21 5QW, UK.
Edward D NicolAcademic Department of Military Rehabilitation (ADMR), Defence Medical Rehabilitation Centre (DMRC), Stanford Hall, Loughborough, LE21 5QW, UK.
Oliver J RiderDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.
David A HoldsworthDepartment of Cardiology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK. david.holdsworth@ouh.nhs.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBoth obesity and cardiorespiratory fitness are crucial determinants of symptoms and prognosis. However, interpreting the gold-standard cardiopulmonary exercise test (CPET) is complicated by increasing body size and varying body composition. We hypothesised that the 'metabolic cost of external work' (or oxygen uptake (ml/min)/workload (Watts); V̇O

methodsA test cohort of 160 fit individuals underwent anthropomorphic and metabolic assessment, maximal bicycle ergometer CPET, and six-minute walk test (6MWT). V̇O

resultsIn both test and validation cohort, V̇O

conclusionMetabolic cost is strongly associated with functional capacity and metabolic health across a range of body weight and fitness, outperforming standard CPET metrics. It is a simple measure which may improve our assessment of the extent to which exertional symptoms are determined by metabolic factors in an individual, and thereby target the most appropriate intervention to those who will benefit most.

Indexed as

Energy MetabolismExerciseExercise TestObesityOxygen ConsumptionAdultAgedCardiorespiratory FitnessFemaleHumansMaleMiddle AgedCardiopulmonary exercise testCardiorespiratory fitnessMetabolic syndromeObesity

Identifiers

PMID40913130
PMCPMC12948812

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.