ArticleJournal of the American Heart Association2025
Microvascular Occlusion and Postrecanalization Hyperperfusion in a Swine Model of Acute Ischemic Stroke.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Article
- Evaluation of coronary artery lesions in children with Kawasaki disease by coronary angiography.BMC pediatrics · 2026Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite successful recanalization after endovascular thrombectomy, more than half of patients with acute ischemic stroke with large-vessel occlusions experience an unsatisfactory outcome. Incomplete microvascular reperfusion may contribute to it, but its occurrence remains debated, partly due to clinical observations of hyperperfusion after recanalization. This study investigates the relationship between ischemia duration, infarct development, microclot presence, and cerebral perfusion in a swine model of focal cerebral ischemia and reperfusion.
methodsTwenty-three swine underwent craniectomy and were randomized into 5 groups: 1-hour, 2-hour, or 4-hour occlusion followed by 4-hour recanalization, 8-hour occlusion without recanalization (positive control), or without occlusion (sham). Middle cerebral artery occlusion was induced using aneurysm clips, with 3-dimensional digital subtraction angiography confirming occlusion and recanalization. Three-dimensional digital subtraction angiography was used for quantification of area at risk and tissue perfusion. Infarct size was measured using 2,3,5-triphenyl-2H-tetrazolium chloride staining. The presence of microclots was quantified using CD61+ platelet immunostaining (number/mm
resultsArea at risk-normalized infarct size increased significantly with ischemia duration (
conclusionsFocal cerebral ischemia and reperfusion result in a substantial presence of microclots, which occurs alongside hyperperfusion in this swine model of recanalized acute ischemic stroke. These platelet microclots extend beyond the ischemic area. The density of microclots within the ischemic region increased with prolonged ischemia.
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