Evidence map›Paper›PMID 40913446›Full record

Trial reportMovement disorders : official journal of the Movement Disorder Society2025

ENLITE PD: A Randomized Clinical Trial of Light Therapy for Impaired Sleep in Parkinson's Disease.

Aleksandar Videnovic, Christopher S Coffey, Elizabeth B Klerman, Merit Cudkowicz, Hyun Joo Cho, Amy Amara, Karen Marder, Phyllis Zee, Christina Desir, Holly Ernst and 57 more

Abstract readRandomized Controlled TrialClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

67 authors.

Aleksandar VidenovicDepartment of Neurology, Mass General Brigham, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9237-1516
Christopher S CoffeyClinical Trials Statistical and Data Management Center, University of Iowa, Iowa City, Iowa, USA.
Elizabeth B KlermanDepartment of Neurology, Mass General Brigham, Boston, Massachusetts, USA.
Merit CudkowiczDepartment of Neurology, Mass General Brigham, Boston, Massachusetts, USA.
Hyun Joo ChoNational Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-5926-7864
Amy AmaraDepartment of Neurology, University of Colorado, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0003-0762-9656
Karen MarderDepartment of Neurology, Columbia University, New York, New York, USA.
Phyllis ZeeDepartment of Neurology, Northwestern University, Chicago, Illinois, USA.
Christina DesirNeurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA.
Holly ErnstClinical Trials Statistical and Data Management Center, University of Iowa, Iowa City, Iowa, USA.
Erin SteinhartNeurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA.
Michelle CostiganClinical Trials Statistical and Data Management Center, University of Iowa, Iowa City, Iowa, USA.
Anna GudjonsdottirClinical Trials Statistical and Data Management Center, University of Iowa, Iowa City, Iowa, USA.
Elizabeth KlingnerClinical Trials Statistical and Data Management Center, University of Iowa, Iowa City, Iowa, USA.
Dixie EcklundClinical Trials Statistical and Data Management Center, University of Iowa, Iowa City, Iowa, USA.
Marianne ChaseNeurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA.
Amy WangDepartment of Neurology, Mass General Brigham, Boston, Massachusetts, USA.
David CharlesDepartment of Neurology, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-1205-6661
David CliffordDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Juliana ColemanDepartment of Neurology, University of Alabama, Birmingham, Alabama, USA.
Alberto J EspayDepartment of Neurology, University of Cincinnati, Cincinnati, Ohio, USA.
Albert Y HungDepartment of Neurology, Mass General Brigham, Boston, Massachusetts, USA.
Srinath KadimiDepartment of Neurology, Yale University, New Haven, Connecticut, USA.
Annie KilloranDepartment of Neurology, University of Iowa, Iowa City, Iowa, USA.
Lan LuoDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Roneil MalkaniDepartment of Neurology, Northwestern University, Chicago, Illinois, USA.
Jason MargoleskyDepartment of Neurology, University of Miami, Miami, Florida, USA.ORCID https://orcid.org/0000-0001-8976-2500
Jennifer MarsellaDepartment of Neurology, University of Rochester, Rochester, New York, USA.
Carine MaurerDepartment of Neurology, State University of New York at Stony Brook, Stony Brook, New York, USA.ORCID https://orcid.org/0000-0002-7892-7127
Dragos MihailaDepartment of Neurology, State University of New York Upstate Medical University, Syracuse, New York, USA.
Paolo MorettiDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Ariane ParkDepartment of Neurology, Ohio State University, Columbus, Ohio, USA.
Nicolas PhielippDepartment of Neurology, University of California Irvine, Irvine, California, USA.ORCID https://orcid.org/0000-0002-4631-7551
Harini SarvaDepartment of Neurology, Cornell University, New York, New York, USA.
Binit ShahDepartment of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Holly A ShillDepartment of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA.
Andrew SiderowfDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Valerie SuskiDepartment of Neurology, University of Pittsburg, Pittsburg, Pennsylvania, USA.
Jessica TateDepartment of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Winona TseDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kara WyantDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Lin ZhangDepartment of Neurology, University of California Davis, Sacramento, California, USA.
Christine AnnisDepartment of Neurology, University of Rochester, Rochester, New York, USA.
Katherine AmbrogiDepartment of Neurology, Ohio State University, Columbus, Ohio, USA.
Gabrielle AuerbachDepartment of Neurology, Cornell University, New York, New York, USA.
Melanie BengeDepartment of Neurology, University of Alabama, Birmingham, Alabama, USA.
Emma BlystoneDepartment of Neurology, State University of New York Upstate Medical University, Syracuse, New York, USA.
Loraine BrennerDepartment of Neurology, University of Iowa, Iowa City, Iowa, USA.
Carolina Burgos AguilarDepartment of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Grace BwalaDepartment of Neurology, Mass General Brigham, Boston, Massachusetts, USA.
Juliana DorschDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Erica GoudeDepartment of Neurology, University of California Davis, Sacramento, California, USA.
Hilda GutierrezDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Kelly HarperDepartment of Neurology, Vanderbilt University, Nashville, Tennessee, USA.
Samuel HochbergerDepartment of Neurology, Cornell University, New York, New York, USA.
Priyanka KalyaniDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jessica LambDepartment of Neurology, State University of New York at Stony Brook, Stony Brook, New York, USA.
Kay MaupinDepartment of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Angela MolloyDepartment of Neurology, University of Cincinnati, Cincinnati, Ohio, USA.
Sherri MosovskyDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mysha SissineDepartment of Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Julie SteeleDepartment of Neurology, University of Miami, Miami, Florida, USA.
Monica SzelaDepartment of Neurology, Northwestern University, Chicago, Illinois, USA.
Mangesha TeshomeDepartment of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Marie WencelDepartment of Neurology, University of California Irvine, Irvine, California, USA.
Eric A MacklinDepartment of Neurology, Mass General Brigham, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1618-3502
NeuroNEXT NN110 ENLITE PD Investigators

Funding

Clinical Coordinating Center Network of Excellence in Neuroscience Clinical TrialU01NS077179 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Merit E CUDKOWICZ, Aleksandar Videnovic · 2011 to 2026
$43.4M
Network of Excellence in Neuroscience Clinical Trials (NEXT)-DCCU01NS077352 · NINDS · UNIVERSITY OF IOWA · PI CHRISTOPHER S. COFFEY · 2011 to 2026
$28.1M
A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson's DiseaseU01NS114001 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VIDENOVIC, ALEKSANDAR · 2019 to 2021
$6.5M
University of Rochester Clinical Site within the NEXT Network of Clinical TrialsU24NS107165 · NINDS · UNIVERSITY OF ROCHESTER · PI ROBERT G. HOLLOWAY · 2018 to 2026
$3.2M
NINDS NIH HHS U01 NS077179NINDS NIH HHS U01 NS077352NINDS NIH HHS U01 NS114001NINDS NIH HHS U01NS114001NINDS NIH HHS U24 NS107165
6 · The paper itself

Abstract

backgroundLight therapy (LT) in Parkinson's disease improves sleep. Specific LT parameters require further study, including optimal frequency.

objectivesWe aimed to determine if once- or twice-daily bright white light therapy (BWLT) improves sleep. Secondary aims compared once-weekly BWLT to twice-daily dim red light therapy (DRLT) as controls, estimated effects on fatigue, and adherence.

methodsA 16-week, randomized, phase 2, sham-controlled, dose-selection trial to select the superior BWLT frequency based on change in Parkinson's Disease Sleep Scale-2 (PDSS-2), participant burden, and safety. Participants were randomized to 8 weeks of twice-daily BWLT, once-daily BWLT, once-weekly BWLT, or twice-daily DRLT. An improvement of ≥1.7 points in 8-week change of PDSS-2 by daily BWLT relative to either control warranted advancing to a phase 3 trial.

resultsA total of 150 participants were randomized (mean [SD], 67 [8.6] years; 57 [38%] female; PDSS-2 17.1 [6.7]). Mean 8-week change from baseline in PDSS-2 score improved (twice-daily BWLT -2.6 [95% CI: -4.4, -0.7]; once-daily BWLT -1.5 [-3.3, 0.3]; once-weekly BWLT -0.4 [-2.2, 1.4]; twice-daily DRLT -1.8 [-3.6, 0.1]) but did not meet criteria for advancing. Mean 8-week change from baseline in Parkinson's Disease Fatigue Scale (PFS-16) score improved (twice-daily BWLT -6.4 [-9.8, -3.0]; once-daily BWLT -2.2 [-5.5, 1.1]; once-weekly BWLT -0.5 [-3.9, 2.8]; and twice-daily DRLT -3.8 [-7.3, -0.4]). Mean adherence to LT was 63%-86%.

conclusionsENLITE-PD did not meet the criteria for advancing daily LT to a phase 3 trial. LT was safe and well-tolerated with good adherence. Once-weekly BWLT was a non-inferior control compared with twice-daily DRLT. © 2025 International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

Indexed as

Parkinson DiseasePhototherapySleep Wake DisordersAgedFatigueFemaleHumansMaleMiddle AgedSeverity of Illness IndexTreatment Outcomefatiguelight therapyParkinson'ssleepsleep disturbance

Identifiers

PMID40913446
PMCPMC13287846

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.