Evidence map›Paper›PMID 40913631›Full record

ReviewJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2025

The important interplay between metal ions and the intermediate filament protein vimentin.

Estely J Carranza, Dylan T Murray, Marie C Heffern

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Metal Ion Binding of Vimentin Tail Domain Fragments.Chembiochem : a European journal of chemical biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Estely J CarranzaDepartment of Chemistry, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0001-5023-1120
Dylan T MurrayDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA. dylan.murray@uconn.edu.ORCID http://orcid.org/0000-0001-7501-2741
Marie C HeffernDepartment of Chemistry, University of California, Davis, CA, USA. mcheffern@ucdavis.edu.ORCID http://orcid.org/0000-0002-2402-810X

Funding

Supplement: Metalloendocrinology: Mapping Bioinorganic Chemistry in the Extracellular SpaceR35GM133684 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HEFFERN, MARIE C. · 2019 to 2023
$2.0M
Low-complexity domain protein molecular structure, conformational dynamics, and inter-protein interactions in human health and diseaseR35GM142892 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI MURRAY, DYLAN THOMAS · 2021 to 2025
$1.9M
UC Davis Training Program in Chemical BiologyT32GM136597 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHEILA Sue DAVID, Marie C. Heffern · 2021 to 2026
$1.7M
NIGMS NIH HHS R35 GM133684NIGMS NIH HHS R35 GM142892NIGMS NIH HHS T32 GM136597NIH HHS R35GM133684NIH HHS R35GM142892NIH HHS T32GM136597
6 · The paper itself

Abstract

Vimentin is a principal intermediate filament (IF) protein that is essential for maintaining cytoskeleton architecture and cellular mechanical integrity. Growing evidence is revealing that metal ions play critical roles in modulating the structure, assembly, and mechanics of vimentin IFs. Despite this, a detailed molecular-level understanding of vimentin-metal interactions and its functional consequences remains incomplete. This review summarizes the current knowledge of metal-induced effects on the structural and mechanical properties of vimentin and highlights how post-translational modifications and cytoskeletal dynamics may alter these metal-protein interactions. Advancing our understanding of the interplay between metal ions and vimentin IFs will enhance our comprehension of the complex mechanisms governing the versatile functions of vimentin and other IF proteins in health and disease.

Indexed as

MetalsVimentinAnimalsHumansIntermediate FilamentsIonsProtein Processing, Post-TranslationalIonsMetalsVimentinAssemblyIntermediate filamentMetalsPost-translational modificationsStructureVimentin

Identifiers

PMID40913631
PMCPMC13214994

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.