Evidence map›Paper›PMID 40913838›Full record

SynthesisSeminars in arthritis and rheumatism2025

Healthy dietary pattern and risk of rheumatoid arthritis: A systematic review and meta-analysis.

Elena K Joerns, Jeffrey A Sparks, Cynthia J Chelf, Cynthia S Crowson, John M Davis, Vanessa L Kronzer

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Seminars in arthritis and rheumatism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elena K JoernsDivision of Rheumatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. Electronic address: Joerns.elena@mayo.edu.
Jeffrey A SparksDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital & Harvard Medical School, 850 Boylston St #540, Chestnut Hill, MA 02467, USA. Electronic address: jsparks@bwh.harvard.edu.
Cynthia J ChelfMayo Clinic College of Medicine and Science, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. Electronic address: chelf.cynthia@mayo.edu.
Cynthia S CrowsonDivision of Rheumatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA; Department of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. Electronic address: crowson@mayo.edu.
John M DavisDivision of Rheumatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. Electronic address: davis.john4@mayo.edu.
Vanessa L KronzerDivision of Rheumatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA; Department of Quantitative Health Sciences, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. Electronic address: kronzer.vanessa@mayo.edu.

Funding

VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel Hal Solomon · 2017 to 2026
$9.8M
Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung DiseaseR01AR077607 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SPARKS, JEFFREY ANDREW · 2021 to 2025
$3.7M
Rheumatoid Arthritis-associated Parenchymal Lung Disease: Clinical and Molecular PhenotypesR01HL155522 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Jeffrey Andrew Sparks, George R Washko · 2022 to 2026
$3.5M
Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic DiseasesR01AR080659 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Jeffrey Andrew Sparks · 2023 to 2026
$2.9M
NHLBI NIH HHS R01 HL155522NIAMS NIH HHS P30 AR070253NIAMS NIH HHS P30 AR072577NIAMS NIH HHS R01 AR077607NIAMS NIH HHS R01 AR080659
6 · The paper itself

Abstract

objectivesWe aimed to determine the degree to which a healthy dietary pattern is associated with incident rheumatoid arthritis (RA).

methodsWe registered this systematic review and meta-analysis in PROSPERO (CRD42025645056). Inclusion criteria were validated diet (anti-inflammatory, Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and/or healthy eating index [HEI]); validated RA definition; dietary exposure preceding RA; and randomized controlled trial, cohort, or case-control design. We searched CENTRAL, Embase, MEDLINE, Scopus, Web of Science, and grey literature as of 2/3/2025. We assessed risk of bias using the Newcastle-Ottawa Scale. Meta-analyses combined adjusted odds ratios (OR) with 95 % confidence interval (CI) for incident RA using random effects models. For heterogeneity, we calculated I

resultsWe included 12 case-control and cohort studies (8 of which were independent) in the review. Three studies were low risk of bias, 3 moderate, 3 high, and 3 very high. Healthy overall dietary pattern was associated with lower risk of incident RA (OR 0.54, 95 % CI 0.32-0.91, I

conclusionsIn observational studies, healthy dietary pattern is associated with reduced risk of incident RA.

Indexed as

Arthritis, RheumatoidDiet, HealthyDiet, MediterraneanHumansRisk FactorsDietEpidemiologyMeta-analysisRheumatoid arthritisSystematic review

Identifiers

PMID40913838
PMCPMC12666885

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.