Evidence map›Paper›PMID 40914285›Full record

SynthesisClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2026

Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity.

Riya Sood, Lisa A Kilpatrick, Laurie A Keefer, Arpana Church

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Riya SoodDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; University of Texas Medical Branch, John Sealy School of Medicine, Galveston, Texas.
Lisa A KilpatrickVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; Goodman Luskin Microbiome Center, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, Los Angeles, California; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Laurie A KeeferDivision of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.
Arpana ChurchVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, California; Goodman Luskin Microbiome Center, University of California, Los Angeles, Los Angeles, California; G. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles, Los Angeles, California; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. Electronic address: arpanachurch@mednet.ucla.edu.

Funding

Social Isolation and Discrimination as Stressors Influencing Brain-Gut Microbiome Alterations among Filipino and Mexican AmericanR01MD015904 · NIMHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2023 to 2025
$2.4M
NIDDK NIH HHS K23 DK106528NIDDK NIH HHS R03 DK121025NIMHD NIH HHS R01 MD015904
6 · The paper itself

Abstract

Despite significant advances in the understanding of the pathogenesis of obesity and influencing factors, its prevalence continues to increase at an alarming rate. Social determinants of health (SDOH) encompass a broad range of psychosocial and environmental factors, including economic stability, education, access to health care, social support, isolation, neighborhood disadvantage, discrimination, early life adversity, and stress, all of which have been recognized to significantly increase the risk of obesity. This review aims to elucidate the intricate relationship between SDOH and biological mechanisms related to the brain-gut-microbiome (BGM) system that lead to altered eating behaviors and obesity. We conducted a systematic review of the current literature to discuss how SDOH contribute to the development, progression, and management of obesity; and on the BGM mechanisms involved in the influence of SDOH on obesity. The BGM mediates the relationship between SDOH and obesity via orexogenic peptides, inflammatory markers, and neuroactive metabolites that affect ingestion-related decision-making and mood. Dysregulations in the BGM system as a result of environmental stressors can contribute to physiological changes in the gut microbial composition, hypothalamic-pituitary-adrenal axis signaling, and structural changes in the reward network, collectively leading to an increased drive toward the consumption of calorie-dense foods. By recognizing and addressing the impact of various SDOH on BGM interactions, health care providers can provide a more equitable and personalized approach that will enhance treatment adherence and the quality of life for individuals with obesity.

Indexed as

BrainGastrointestinal MicrobiomeObesitySocial Determinants of HealthHumansBrain-Gut-Microbiome SystemEating BehaviorsHealth DisparitiesObesitySocial Determinants of Health

Identifiers

PMID40914285
PMCPMC13265241

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.