Evidence map›Paper›PMID 40914329›Full record

ArticleGastroenterology2026

The Prevalence and Burden of Avoidant/Restrictive Food Intake Disorder Symptoms in Adults With Disorders of Gut-Brain Interaction: A Population-Based Study.

Rosie Flack, Grace Brownlow, Helen Burton-Murray, Olafur Palsson, Imran Aziz

Abstract read
In one paragraph

Article in Gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Avoidant-Restrictive Food Intake Disorder in Patients With Gastrointestinal Disorders: A Systematic Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Pooled it
  2. Article
  3. Review
  4. Letter: Low-FODMAP Diet in Irritable Bowel Syndrome-Beyond the Hype!Alimentary pharmacology & therapeutics · 2026
    Article
  5. Quality of Life in Adults with Eating Disorders.Behavioral sciences (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Authors' response.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rosie FlackDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, United Kingdom; Academic Department of Gastroenterology, Sheffield Teaching Hospitals, Sheffield, United Kingdom.
Grace BrownlowDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, United Kingdom; Academic Department of Gastroenterology, Sheffield Teaching Hospitals, Sheffield, United Kingdom.
Helen Burton-MurrayDepartment of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Olafur PalssonCenter for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Imran AzizDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, United Kingdom; Academic Department of Gastroenterology, Sheffield Teaching Hospitals, Sheffield, United Kingdom. Electronic address: imran.aziz1@nhs.net.

Funding

A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional DyspepsiaK23DK131334 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BURTON MURRAY, HELEN · 2021 to 2025
$1.1M
NIDDK NIH HHS K23 DK131334
6 · The paper itself

Abstract

BACKGROUND &

aimsIndividuals with disorders of gut-brain interaction (DGBI) may experience avoidant/restrictive food intake disorder (ARFID) symptoms. However, extant findings have been limited to specialist neurogastroenterology clinics. We assessed the association between DGBI and ARFID within the adult general population.

methodsA population-based Internet survey with predefined demographic quotas was conducted across the United Kingdom and the United States in 2023. The survey included the Rome IV diagnostic questionnaire for DGBI, the Nine-Item ARFID Screen, and questions regarding demographics, body mass index, nongastrointestinal somatic symptoms, anxiety and depression, quality of life, and healthcare use.

resultsIn this study, 4002 adults (median age, 46 [range, 18-91] years; 50% female) completed the survey, of whom 1704 (42.6%) had symptoms compatible with at least 1 DGBI. The prevalence of ARFID-positive screens was significantly higher among participants with DGBI compared with those without DGBI (34.6% vs 19.4%; adjusted odds ratio, 1.67; 95% confidence interval, 1.43-1.94), with similar findings noted in each country. Among participants with DGBI, positive ARFID screens using the Nine-Item ARFID Screen subscale were lack of interest in eating (21.5%), sensory-based avoidance (18.1%), and fear of aversive consequences (9.9%). The presence of ARFID increased with the number of DGBI anatomic regions, ranging from 19.4% in those with no DGBI, 27.7% with DGBI in 1 region, 39.5% for DGBI in 2 regions, 50.0% for DGBI in 3 regions, and 61.4% for DGBI in 4 regions (P < .001). Individuals with DGBI plus ARFID, compared with those with DGBI alone, were significantly more likely to be underweight (7.9% vs 1.5%), have greater nongastrointestinal somatic symptoms and psychological distress, reduced mental and physical quality of life, and increased healthcare use.

conclusionsPositive ARFID screens are common in DGBI and associated with increased general health burden. Routine screening for ARFID in DGBI will inform the multi-integrated care plan provided by clinicians, dietitians, and psychologists.

Indexed as

Avoidant Restrictive Food Intake DisorderBrain-Gut AxisAdolescentAdultAgedAged, 80 and overCost of IllnessCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceQuality of LifeSurveys and QuestionnairesUnited KingdomARFIDDisorders of Gut-Brain InteractionFunctional DyspepsiaHealthcare UseIrritable Bowel Syndrome

Identifiers

PMID40914329
PMCPMC13220894

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.