Evidence map›Paper›PMID 40914450›Full record

ArticleNeuroImage2025

Brain metabolite concentrations in neonates with congenital heart disease before and after cardiac surgery.

Steve C N Hui, Nickie Andescavage, Julius S Ngwa, Kushal Kapse, Jonathan G Murnick, Mary T Donofrio, Adre J du Plessis, Catherine Limperopoulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Steve C N HuiDeveloping Brain Institute, Children's National Hospital, Washington, D.C., USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.
Nickie AndescavageDeveloping Brain Institute, Children's National Hospital, Washington, D.C., USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA; Division of Neonatology, Children's National Hospital, Washington, D.C., USA.
Julius S NgwaDeveloping Brain Institute, Children's National Hospital, Washington, D.C., USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.
Kushal KapseDeveloping Brain Institute, Children's National Hospital, Washington, D.C., USA.
Jonathan G MurnickDeveloping Brain Institute, Children's National Hospital, Washington, D.C., USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA; Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, D.C., USA.
Mary T DonofrioDepartment of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA; Division of Cardiology, Children's National Hospital, Washington, D.C., USA.
Adre J du PlessisDeveloping Brain Institute, Children's National Hospital, Washington, D.C., USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA; Prenatal Pediatric Institute, Children's National Hospital, Washington, D.C., USA.
Catherine LimperopoulosDeveloping Brain Institute, Children's National Hospital, Washington, D.C., USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA; Prenatal Pediatric Institute, Children's National Hospital, Washington, D.C., USA. Electronic address: CLimpero@childrensnational.org.

Funding

Antecedents of Impaired Brain Development in Fetuses with Heart DiseaseR01HL116585 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI LIMPEROPOULOS, CATHERINE · 2013 to 2017
$3.8M
Impaired Brain Development in a Premature Ex-utero EnvironmentR01HD099393 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI DU PLESSIS, ADRE JACQUES, LIMPEROPOULOS, CATHERINE · 2020 to 2024
$3.4M
NHLBI NIH HHS R01 HL116585NICHD NIH HHS R01 HD099393
6 · The paper itself

Abstract

The purpose of this study was to compare brain metabolite concentrations between healthy and CHD neonates before and after cardiac surgery. Healthy term newborns and neonates with CHD were recruited prospectively. T

Indexed as

BrainCardiac Surgical ProceduresHeart Defects, CongenitalFemaleHumansInfant, NewbornMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleBrain metabolitesCardiac surgeryCongenital heart diseaseGamma-aminobutyric acidNeonatesProton magnetic resonance spectroscopy

Identifiers

PMID40914450
PMCPMC13093490

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.