ArticleMolecular pharmaceutics2025
Canine Mdr1 Knockout MDCK Cells Reliably Estimate Human Small Intestinal Permeability (
Kristian Beran, Seong Hee Park, An Van den Bergh, Jennifer Dressman, Eline Hermans, René Holm, Yanping Lin, Kia Sepassi, Bin Yang, Raymond Evers
Abstract read
In one paragraphArticle in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Kristian BeranFraunhofer Institute for Translational Medicine and Pharmacology, 60596 Frankfurt am Main, Germany.ORCID 0000-0001-7918-0865 Seong Hee ParkJohnson & Johnson, Translational PK/PD & Investigational Toxicology, Spring House, Pennsylvania 19002, United States.
An Van den BerghJohnson & Johnson, Translational PK/PD & Investigational Toxicology, 2340 Beerse, Belgium.
Jennifer DressmanFraunhofer Institute for Translational Medicine and Pharmacology, 60596 Frankfurt am Main, Germany.
Eline HermansJohnson & Johnson, Pharmaceutical & Material Sciences, 2340 Beerse, Belgium.
René HolmUniversity of Southern Denmark, Department of Physics, Chemistry and Pharmacy, 5230 Odense, Denmark.ORCID 0000-0003-4894-7765 Yanping LinMedpace Bioanalytical Laboratory, Cincinnati, Ohio 45277, United States.
Kia SepassiJohnson & Johnson, Discovery Pharmaceutics, San Diego, California 92121, United States.
Bin YangJohnson & Johnson, Bioanalytical Discovery & Development Sciences, Spring House, Pennsylvania 19002, United States.
Raymond EversJohnson & Johnson, Translational PK/PD & Investigational Toxicology, Spring House, Pennsylvania 19002, United States.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Human intestinal permeability is a key determinant of the oral fraction absorbed (
Indexed as
Intestinal AbsorptionPharmaceutical PreparationsAcetaminophenAdministration, OralAnimalsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1BenzaldehydesBenzenesulfonamidesCRISPR-Cas SystemsDogsGene Knockout TechniquesHumansIntestinal Barrier FunctionIntestine, SmallMadin Darby Canine Kidney CellsABCB1 protein, humanAcetaminophenATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1BenzaldehydesBenzenesulfonamidesfedratinibistradefyllinelemborexantPharmaceutical PreparationsPurinesPyrazinesPyrazolesPyridinesPyrimidinesPyrrolidinesVoriconazolevoxelotorbiopharmaceutics classification system (BCS)oral drug absorptionpermeabilityphysiologically based biopharmaceutics modeling (PBBM)refined developability classification system (rDCS)
Identifiers
PMID40914889
PMCPMC12505271
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390