Evidence map›Paper›PMID 40915408›Full record

ArticleThe Journal of investigative dermatology2026

Tick Extracellular Vesicles Alter Epidermal Keratinocyte Function.

Liron Marnin, Luisa M Valencia, Haikel N Bogale, Hanna J Laukaitis-Yousey, Agustin Rolandelli, Camila Rodrigues Ferraz, Anya J O'Neal, Axel D Schmitter-Sánchez, Emily Bencosme Cuevas, Thu-Thuy Nguyen and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Liron MarninDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Luisa M ValenciaDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Haikel N BogaleInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA; Rancho BioSciences, San Diego, California, USA.
Hanna J Laukaitis-YouseyDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Agustin RolandelliDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA; University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
Camila Rodrigues FerrazDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Anya J O'NealDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Axel D Schmitter-SánchezDivision of Dermatology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA; Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA; Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, Michigan, USA.
Emily Bencosme CuevasDepartment of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Thu-Thuy NguyenDepartment of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Brenda Leal-GalvanDepartment of Entomology, Texas A&M University, College Station, Texas, USA.
David M RickertDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
M Tays MendesDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil; Fiocruz-Bi-Institutional Translational Medicine Project, Ribeirão Preto, Brazil.
Sourabh SamaddarDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Lyme Disease Research Center, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
L Rainer ButlerDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Nisha SinghDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Department of Biotechnology, School of Energy Technology, Pandit Deendayal Energy University, Gujarat, India.
Francy E Cabrera PazDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Alejandra Wu-ChuangDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jonathan D OliverDivision of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Julie M JamesonDepartment of Biology, California State University San Marcos, San Marcos, California, USA.
Ulrike G MunderlohDepartment of Entomology, University of Minnesota, Minneapolis, Minnesota, USA.
Adela S Oliva ChávezDepartment of Entomology, Texas A&M University, College Station, Texas, USA; Department of Entomology, University of Wisconsin, Madison, Wisconsin, USA.
Albert MulengaDepartment of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Sangbum ParkDivision of Dermatology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA; Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA; Institute for Quantitative Health Science & Engineering, Michigan State University, East Lansing, Michigan, USA.
David SerreDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA. Electronic address: jpedra@som.umaryland.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Michael Jason de la Cruz · 1985 to 2026
$347.4M
Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Jonathan D Oliver · 2018 to 2026
$13.5M
Ubiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2M
Tick Saliva and Pathogen TransmissionR01AI134696 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Joao Pedra · 2018 to 2026
$5.1M
Signaling Pathways in Innate ImmunityT32AI095190 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Stefanie N. Vogel · 2012 to 2026
$4.7M
Understanding immune-epithelial interactions during wound repair in live mammalsR01AR083086 · NIAMS · MICHIGAN STATE UNIVERSITY · PI Sangbum Park · 2023 to 2026
$1.9M
Systems-Level Research in Microbial PathogenesisT32AI162579 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI NICHOLAS H CARBONETTI, Julie Dunning Hotopp · 2022 to 2026
$1.7M
Subversion of Keratinocyte Function by a Tick Salivary ProteinR21AI178839 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2024 to 2025
$428k
Characterization of a Lipid Receptor in Tick Humoral ImmunityF31AI152215 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI O’NEAL, ANYA JOSEPHINE · 2020 to 2021
$81k
Rab27 in tick extracellular vesicle biogenesisF31AI167471 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BUTLER, LILLIAN RAINER · 2022 to 2023
$77k
NCI NIH HHS P30 CA008748NIAID NIH HHS F31 AI152215NIAID NIH HHS F31 AI167471NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI116523NIAID NIH HHS R01 AI134696NIAID NIH HHS R21 AI178839NIAID NIH HHS T32 AI095190NIAID NIH HHS T32 AI162579NIAMS NIH HHS R01 AR083086
6 · The paper itself

Abstract

Wound healing has been extensively studied through the lens of inflammatory disorders and cancer, but limited attention has been given to hematophagy and arthropod-borne diseases. Hematophagous ectoparasites, including ticks, subvert the wound healing response to maintain prolonged attachment and facilitate blood feeding. In this study, we unveil a strategy through which extracellular vesicles ensure blood feeding and arthropod survival in 3 medically relevant tick species. Through single-cell RNA sequencing and murine genetics, we demonstrate that wild-type animals infested with Ixodes scapularis that produce fewer extracellular vesicles display a unique epidermal subpopulation with a mesenchymal-like transcriptional program and an overrepresentation of pathways connected to wound healing. Furthermore, tick extracellular vesicles inhibit proliferation and diminish the capacity of gap closure in keratinocytes using an in vitro scratch assay. This occurrence was linked to phosphoinositide 3-kinase activity, keratinocyte GF 1, and TGF-β levels. Collectively, we uncovered a strategy employed by a blood-feeding arthropod that disrupts the circuitry in cutaneous wound healing, contributing to ectoparasite fitness.

Indexed as

EpidermisExtracellular VesiclesIxodesKeratinocytesWound HealingAnimalsCell ProliferationHumansMiceMice, Inbred C57BLModelsMouseWound healing

Identifiers

PMID40915408
PMCPMC12603915

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.