Evidence map›Paper›PMID 40916339›Full record

ArticleThe Korean journal of internal medicine2025

Impact of guideline-directed medical therapy on the cardiac or non-cardiac death in acute myocardial infarction.

Jin-Ho Choi, Dahee Hyun, Seung Ho Hur, Seung Woon Rha, Seung Jae Joo, Hyo-Soo Kim, Myung Ho Jeong, KAMIR-NIH investigators

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jin-Ho ChoiDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Dahee HyunSungkyunkwan University School of Medicine, Seoul, Korea.
Seung Ho HurDepartment of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Korea.
Seung Woon RhaDepartment of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
Seung Jae JooDepartment of Internal Medicine, Jeju University Hospital, Jeju, Korea.
Hyo-Soo KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Myung Ho JeongDepartment of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.
KAMIR-NIH investigatorsDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Funding

National Institute of Health Research Project 2016-ER6304-02
6 · The paper itself

Abstract

BACKGROUND/

aimsWhile the clinical effectiveness of guideline-directed medical therapy (GDMT) is well established in patients with acute myocardial infarction (AMI), its specific impact on cause-specific mortality remains unclear. This study aimed to investigate the impact of GDMT on both cardiac and non-cardiac mortality in AMI patients.

methodsData of the KAMIR-NIH, a multicenter prospective registry of AMI in Korea between 2011 and 2015, were included. The competing risks of cardiac and non-cardiac death in patients who received GDMT were compared with those who did not, using a multivariable-adjusted cumulative incidence analysis of propensity score-matched patients. Primary endpoint of interest was 3-year cardiac and non-cardiac mortality.

resultsOf the 12,815 patients enrolled, 2,700 matched pairs with a mean age of 64.9 ± 12.2 years were analyzed. The cumulative incidence of cardiac death (5.0% vs. 8.6%; subdistribution hazard ratio [sHR] 0.53; 95% CI 0.43-0.67) and non-cardiac death (3.2% vs. 4.5%; sHR 0.69; 95% CI 0.52-0.92) was significantly lower in patients receiving GDMT compared to those who did not (all p < 0.05). These results were also consistent in 30-day landmark analyses.

conclusionIn patients with AMI, the use of GDMT was linked to a reduced risk of both cardiac and non-cardiac death over a period of 3 years. These findings support the continued adoption of GDMT in clinical practice.

Indexed as

Cardiovascular AgentsGuideline AdherenceMyocardial InfarctionPractice Guidelines as TopicAgedCause of DeathFemaleHumansIncidenceMaleMiddle AgedMultivariate AnalysisPropensity ScoreProspective StudiesRegistriesRepublic of KoreaCardiovascular AgentsAcute myocardial infarctionCardiac deathCompeting riskGuideline-directed medical therapyNon-cardiac death

Identifiers

PMID40916339
PMCPMC12425685

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.