Evidence map›Paper›PMID 40916534›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2025

[High expression of SURF4 promotes migration, invasion and proliferation of gastric cancer cells by inhibiting tight junction proteins].

Ziliang Wang, Xiaohua Chen, Jingjing Yang, Chen Yan, Zhizhi Zhang, Bingyi Huang, Meng Zhao, Song Liu, Sitang Ge, Lugen Zuo and 1 more

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Ziliang WangGraduate School, Bengbu Medical University, Bengbu 233030, China.
Xiaohua ChenGraduate School, Bengbu Medical University, Bengbu 233030, China.
Jingjing YangGraduate School, Bengbu Medical University, Bengbu 233030, China.
Chen YanAnhui Provincial Key Laboratory of Research on the Basis and Transformation of Inflammation-related Diseases, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Zhizhi ZhangAnhui Provincial Key Laboratory of Research on the Basis and Transformation of Inflammation-related Diseases, First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Bingyi HuangGraduate School, Bengbu Medical University, Bengbu 233030, China.
Meng ZhaoGraduate School, Bengbu Medical University, Bengbu 233030, China.
Song LiuGraduate School, Bengbu Medical University, Bengbu 233030, China.
Sitang GeDepartment of Gastrointestinal Surgery.
Lugen ZuoDepartment of Gastrointestinal Surgery.
Deli ChenDepartment of Gastrointestinal Surgery.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study the impact of SURF4 expression level on long-term prognosis of gastric cancer (GC) and biological behaviors of GC cells.

methodsSURF4 expression level in GC and its association with long-term patient prognosis were analyzed using publicly available databases and in 155 GC patients with low and high SURF4 expressions detected immunohistochemically. The Cox proportional hazard model and Kaplan-Meier survival curves were used to analyze independent prognostic predictors of GC and the 5-year survival rate of the patients with different SURF4 expression levels. Informatics analyses were conducted to explore the correlation of SURF4 expression level with immune cell infiltration in GC, SURF4-related differential genes and their associated pathways. In cultured GC cell line HGC-27, the effects of SURF4 knockdown and overexpression on proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) were investigated.

resultsAnalysis of GEPIA dataset and immunohistochemical results suggested significant SURF4 overexpression in GC (

conclusionsSURF4 is highly expressed in GC, and its overexpression is associated with a shortened 5-year survival of the patients possibly by enhancing tumor cell proliferation, migration and invasion

Indexed as

Membrane ProteinsStomach NeoplasmsTight Junction ProteinsCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionFemaleHumansMaleNeoplasm InvasivenessPrognosisMembrane ProteinsTight Junction Proteinsepithelial-mesenchymal transitiongastric cancerprognosisSURF4 high expressiontight junction protein

Identifiers

PMID40916534
PMCPMC12415580

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.