ArticleMedical science monitor basic research2025
Therapeutic Mechanisms of Jinshuiqing in IgA Nephropathy: A Transcriptomic Analysis.
Article in Medical science monitor basic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Role of Sirt3 in Kidney Health and Disease.Pharmaceuticals (Basel, Switzerland) · 2025Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND This study aims to explore the therapeutic mechanisms of Jinshuiqing (JSQ) in IgA nephropathy (IgAN) using transcriptomic analysis and animal experimentation. MATERIAL AND METHODS Six-week-old male C57BL/6 mice (20±2 g) were divided into 2 groups: IgAN model and JSQ-treated. The IgAN model was induced in SIRT3 knockout mice with acidified BSA, CCl4, castor oil, and LPS injections. The IgAN group received saline, while the JSQ group was treated with JSQ (4 g/kg/day) for 11 weeks. Following euthanasia, kidney tissues were collected for transcriptomic analysis. RNA extraction and sequencing were performed, followed by differential gene expression and pathway enrichment analysis to assess JSQ's effects. RESULTS PCA and correlation analysis showed distinct differences between the JSQ-treated and control groups. Differential gene expression identified 118 genes with significant changes, indicating that JSQ induces transcriptional alterations. Gene ontology (GO) and KEGG enrichment analyses revealed that JSQ affects pathways related to inflammation, oxidative stress, and metabolism, suggesting its potential to improve kidney function and regulate immune responses in IgAN. CONCLUSIONS JSQ treatment modulates gene expression in IgAN mice, influencing pathways linked to inflammation, gut microbiota, and kidney function. These findings provide insight into how JSQ alleviates inflammation and promotes renal health, offering genetic evidence for its therapeutic efficacy in IgAN.
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