Evidence map›Paper›PMID 40916576›Full record

ReviewJournal of medical virology2025

Insights Into Kaposi Sarcoma-Associated Herpesvirus-Specific Humoral Responses.

Dicle Yalcin, Eric D Eymard, Khushi Kiran, Wema Kibanga, Zhou Liu, Charles Wood, For Yue Tso

Abstract readReview
In one paragraph

Review in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dicle YalcinDepartment of Interdisciplinary Oncology, School of Medicine, Stanley S. Scott Cancer Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Eric D EymardDepartment of Interdisciplinary Oncology, School of Medicine, Stanley S. Scott Cancer Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Khushi KiranDepartment of Interdisciplinary Oncology, School of Medicine, Stanley S. Scott Cancer Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Wema KibangaDepartment of Interdisciplinary Oncology, School of Medicine, Stanley S. Scott Cancer Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Zhou LiuDepartment of Interdisciplinary Oncology, School of Medicine, Stanley S. Scott Cancer Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Charles WoodDepartment of Interdisciplinary Oncology, School of Medicine, Stanley S. Scott Cancer Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.ORCID 0000-0002-4256-1530
For Yue TsoDepartment of Interdisciplinary Oncology, School of Medicine, Stanley S. Scott Cancer Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Funding

Translational Genomics Core (TGC)P20GM121288 · NIGMS · LSU HEALTH SCIENCES CENTER · PI Arunava Roy · 2017 to 2026
$22.4M
Project 3U54CA277846 · NCI · LSU HEALTH SCIENCES CENTER · PI Charles Wood · 2023 to 2026
$4.7M
Models for KHSV transmission and its inhibitionR01CA239591 · NCI · UNIVERSITY OF NEBRASKA LINCOLN · PI WEST, JOHN T., WOOD, CHARLES · 2019 to 2024
$2.1M
Tanzania AIDS Malignancies Training and Research Program (TAMTRP)D43TW012277 · FIC · LSU HEALTH SCIENCES CENTER · PI WOOD, CHARLES · 2022 to 2025
$1.4M
FIC NIH HHS D43 TW012277NCI NIH HHS R01 CA239591NCI NIH HHS U54 CA277846NIGMS NIH HHS P20 GM121288This work was supported by the National Institute of General Medical Sciences (P20 GM121288) to F.Y.T., and National Cancer Institute (CA239591, CA277846), Fogarty International Center (D43TW012277) to C.W. W.K. is a Fogarty Fellow.
6 · The paper itself

Abstract

Kaposi sarcoma (KS) remains a global health concern. In sub-Saharan Africa, where there is a high burden of HIV-1 infection, there is also a high prevalence of infection by the etiologic agent of KS, the KS-associated herpesvirus (KSHV). Despite the successes of antiretroviral treatment (ART), the burden of KS and other KSHV-associated malignancies among people living with HIV under ART remained high, stressing the need for a greater understanding of the immune response against KSHV infection. Here, we review the current information on KSHV-specific humoral response in infected individuals in detail. We discuss the significance of anti-KSHV responses, mechanisms used by KSHV to subvert and modulate humoral immunity, and implications for pathogenesis and therapy. We highlight cutting-edge serological assays and bioinformatics tools that aid the development of effective vaccines against KSHV, underscoring the complexity of the humoral response and its critical role within the context of infection and vaccine design.

Indexed as

Antibodies, ViralHerpesvirus 8, HumanImmunity, HumoralSarcoma, KaposiHIV InfectionsHumansAntibodies, Viralhumoral immunityimmunoinformaticsKSHVserologyvaccine development

Identifiers

PMID40916576
PMCPMC12904286

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.