Evidence mapPaperPMID 40916611Full record

ArticleJournal of neurochemistry2025

Peripheral Inflammation Is Associated With Greater Neuronal Injury and Lower Episodic Memory Among Late Middle-Aged Adults.

Mona-Lisa Malarte, Konstantinos Chiotis, Konstantinos Ioannou, Elena Rodriguez-Vieitez

Abstract read
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mona-Lisa MalarteDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Konstantinos ChiotisDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Konstantinos IoannouDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Elena Rodriguez-VieitezDivision of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-6639-8141

Funding

Clinical and Translational Science AwardUL1TR001873 · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2025 to 2025
$10.0M
Åhlén-stiftelsen 223084Alzheimerfonden AF-1012445Alzheimerfonden AF-968569DemensfondenGun och Bertil Stohnes StiftelseKarolinska InstitutetNCATS NIH HHS UL1 TR001873Neuroförbundet F2022-0036Neuroförbundet F2023-0049Neuroförbundet F2024-0064NIA NIH HHS RF1 AG051556Olle Engkvists Stiftelse 207-0584Stiftelsen för Gamla TjänarinnorStockholms Läns Landsting FoUI-960437Stockholms Läns Landsting FoUI-975492
6 · The paper itself

Abstract

Elucidating the earliest biological mechanisms underlying Alzheimer's disease (AD) is critical for advancing early detection strategies. While amyloid-β (Aβ) and tau pathologies have been central to preclinical AD research, the roles of peripheral biological processes in disease initiation remain underexplored. We investigated patterns of

Indexed as

InflammationMemory, EpisodicNeuronsAgedAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersFemaleHumansMaleMiddle AgedNeurofilament ProteinsPositron-Emission Tomographytau ProteinsAmyloid beta-PeptidesBiomarkersneurofilament protein LNeurofilament Proteinstau Proteins18F‐MK6240 tau PETepisodic memoryneuronal injuryperipheral inflammationplasma NfLpreclinical Alzheimer's disease

Identifiers

PMID40916611
PMCPMC12415539

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.