Evidence map›Paper›PMID 40917517›Full record

ArticleMaterials today. Bio2025

The role of 3D printing in skeletal muscle-on-a-chip models: Current applications and future potential.

Wei Bao, Junyan Liu, Chengcheng Du, Senrui Liu, Jiacheng Liu, Zhenglin Zhu, Liangbin Zhou, Zhong Alan Li, Wei Huang, Yiting Lei

Abstract read
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wei BaoDepartment of Orthopedics, Banan Hospital of Chongqing Medical University, Chongqing, China.
Junyan LiuDepartment of Orthopedics, Banan Hospital of Chongqing Medical University, Chongqing, China.
Chengcheng DuDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Senrui LiuDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jiacheng LiuDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhenglin ZhuDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liangbin ZhouDepartment of Biomedical Engineering, The Chinese University of Hong Kong, NT, Hong Kong Special Administrative Region of China.
Zhong Alan LiDepartment of Biomedical Engineering, The Chinese University of Hong Kong, NT, Hong Kong Special Administrative Region of China.
Wei HuangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yiting LeiDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organ-on-a-chip (OoC) systems can simulate the key functions of human organs, combining microfluidics, cell culture, and biomaterials. 3D printing can be integrated into these technologies to facilitate the construction of OoC models. The high precision and layer-by-layer fabrication process of 3D printing not only enables the creation of complex structures for the microfluidic chip but also improves the cellular microenvironment within the chip by harnessing bioinks for 3D bioprinting. In recent years, OoC models established with 3D printing technology have successfully replicated the functions of various native organs, significantly advancing disease research and drug development. However, due to the complex anatomical structure and unique physiological functions of skeletal muscle, the application of 3D printing in skeletal muscle-on-a-chip (SMoC) models remains relatively limited. Based on existing research on engineered skeletal muscle and OoC, this review discusses the construction of SMoC models by 3D printing to recapitulate the anatomical structure and physiological functions of skeletal muscle. Furthermore, it explores the different applications of 3D printed SMoC models and the future challenges and prospects in this field.

Indexed as

3D printingMicrofluidic technologyOrgan-on-a-chipSkeletal muscle disordersSkeletal muscle-on-a-chip

Identifiers

PMID40917517
PMCPMC12408411

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.