ReviewMaterials today. Bio2025
Intelligent transdermal nanoparticles as synergizing advanced delivery systems for precision therapeutics.
Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Numerical modelling for hollow pyramidal microneedle-based drug-loaded particles delivery for controlled drug release.Drug delivery and translational research · 2026Article
- Engineering Multi-Scale Transdermal Delivery Systems for Atopic Dermatitis: Emerging Insights from the Gut-Skin Axis.International journal of nanomedicine · 2026Review
- Biofilm-Responsive Nanoplatforms for Infected Wound Reconstruction.International journal of nanomedicine · 2026Review
- Nanotechnology in Skin Cancer Therapy: Recent Progress in Targeted Delivery.The Kaohsiung journal of medical sciences · 2026Review
- Recent advances in polymer-based drug delivery systems for atopic dermatitis: enhancing therapeutic efficacy and outcomes.Materials today. Bio · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transdermal drug delivery systems (TDDS) represent a non-invasive approach to achieve controlled drug release through the skin barrier, offering stable plasma concentrations while avoiding gastrointestinal and hepatic metabolism. However, the skin barrier poses physical challenges, making it difficult for most drugs to penetrate deep tissues using TDDS. This review systematically summarizes the research progress in nanocarrier design, physical technology application, and artificial intelligence (AI)-driven TDDS optimization design aimed at overcoming the key problem of skin barrier penetration. An in-depth analysis of nanocarriers, such as soft vesicles, nanoemulsions, rigid nanoparticles, and physically assisted enhancement technologies, and AI-driven research on skin penetration enhancement in TDDS was summarized. An integrated technical framework demonstrates how microneedle arrays, iontophoresis, electroporation, and photoporation synergize with nanoparticles to achieve spatiotemporally controlled transdermal drug delivery. Additionally, the review emphasizes the clinical application potential of these integrated technologies and offers a comprehensive, multidimensional perspective to advance innovation in TDDS.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.