ReviewRSC advances2025
Nanomaterial-enabled drug delivery systems for circadian medicine: bridging direct rhythm modulation and chronotherapy.
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Melatonin rhythm-mimicking smart hydrogel for circadian clock regulation and promotion of intervertebral disc regeneration.Materials today. Bio · 2026Article
- The Potential of Chronotherapy and Nanotherapy-Based Strategies for Glioblastoma Treatment.Pharmaceutics · 2026Review
- Circadian rhythms in the tumor microenvironment: spatiotemporal immune regulation and chronotherapeutic opportunities.Frontiers in immunology · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian rhythms are essential for maintaining health and homeostasis, and disruptions can lead to sleep disorders, metabolic diseases, cardiovascular diseases, and neurodegenerative conditions. Herein, we discuss the importance of circadian rhythms and the challenges in their regulation, highlighting the limitations of traditional drug delivery methods. Various nanomaterials such as liposomes, polymeric nanoparticles (PNPs), and mesoporous silica nanoparticles have unique physical and chemical properties. These characteristics allow them to deliver drugs to specific targets over a sustained period, which improves the effectiveness of treatments for circadian-related disorders. The article discusses how nanomaterials can be used to combine different treatment strategies to address the many challenges of disrupted circadian rhythms. By delivering several drugs at once, these systems can enhance treatment specificity and reduce side effects, offering a more effective approach to managing conditions such as sleep disorders and mood disorders associated with circadian misalignment. The potential for smart drug delivery systems (SDDSs) that respond to physiological cues, such as temperature or pH changes, is also explored, showcasing how these innovations could lead to more personalized and effective therapies.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.