Evidence map›Paper›PMID 40917690›Full record

ArticleMolecular therapy. Methods & clinical development2025

Reversing PAI-1 deficiency in blood using mRNA lipid nanoparticles.

Francesca Ferraresso, Chad W Skaer, Katherine Badior, Serena M Pulente, Manoj Paul, Laura Ketelboeter, Taylor H S Chen, Pieter R Cullis, Sweta Gupta, Amy Shapiro and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesca FerraressoVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Chad W SkaerVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Katherine BadiorVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Serena M PulenteUniversity of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada.
Manoj PaulVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Laura KetelboeterVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Taylor H S ChenVersiti Blood Research Institute, Milwaukee, WI 53226, USA.
Pieter R CullisDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Sweta GuptaInnovative Hematology/Indiana Hemophilia and Thrombosis Center, Indianapolis IN 46260, USA.
Amy ShapiroInnovative Hematology/Indiana Hemophilia and Thrombosis Center, Indianapolis IN 46260, USA.
Erin E MulvihillUniversity of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada.
Christian J KastrupVersiti Blood Research Institute, Milwaukee, WI 53226, USA.

Funding

Understanding and Controlling the Contribution of Fibrinolysis to Bleeding Using a Long-Acting Antifibrinolytic RNA TherapyR01HL166382 · VERSITI BLOOD HEALTH, INC. · 2025 to 2025
$718k
NHLBI NIH HHS R01 HL166382
6 · The paper itself

Abstract

Plasminogen activator inhibitor-1 (PAI-1) deficiency is a rare disorder that causes moderate to severe bleeding and cardiac fibrosis, caused by mutation in the

Indexed as

bleedingbleeding disordercardiac fibrosisgene therapylipid nanoparticlesmRNANanomedicinePAI-1 deficiencyrare diseaseRNA therapy

Identifiers

PMID40917690
PMCPMC12410550

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.