RUNX1 promotes denervation-induced muscle atrophy by activating the JUNB/NF-κB pathway and driving M1 macrophage polarization.

Wei Hu, Yang Huang, Wei Yin, Yao Huang, Jian Wu

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Article in Open life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Wei HuDepartment of Radiology, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, No. 228, Jingui Road, Xian'an District, Xianning, Hubei, 437000, China.

Yang HuangDepartment of Radiology, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, No. 228, Jingui Road, Xian'an District, Xianning, Hubei, 437000, China.

Wei YinDepartment of Radiology, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, No. 228, Jingui Road, Xian'an District, Xianning, Hubei, 437000, China.

Yao HuangDepartment of Radiology, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, No. 228, Jingui Road, Xian'an District, Xianning, Hubei, 437000, China.

Jian WuDepartment of Radiology, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, No. 228, Jingui Road, Xian'an District, Xianning, Hubei, 437000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral nerve injury-induced muscle atrophy is characterized by chronic inflammation and dysregulated macrophage polarization. RUNX1, a transcription factor upregulated in denervated muscle, has been implicated in linking muscle degeneration to inflammatory processes, but its downstream targets and mechanisms remain unclear. The aim of this study is to delineate the RUNX1-JUNB-NF-κB axis in driving inflammation-mediated muscle atrophy. The GSE183802 single-nucleus RNA sequencing dataset was analyzed to identify RUNX1-associated pathways. A sciatic nerve transection model in mice was established to validate RUNX1 expression dynamics. Chromatin immunoprecipitation, dual-luciferase reporter assays, and siRNA-mediated knockdown were used to confirm RUNX1's transcriptional regulation of

Indexed as

JUNBmacrophagemuscle atrophyNF-κB signalingRUNX1

Identifiers

PMID40917776

DOI10.1515/biol-2025-1157

PMCPMC12412371

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.