ReviewFrontiers in immunology2025
Kaempferol as a multifaceted immunomodulator: implications for inflammation, autoimmunity, and cancer.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Network Pharmacology-Based Exploration of Complementary Molecular Mechanisms of Heat-Clearing (Scutellariae Radix, Coptidis Rhizoma) and Blood-Tonifying Herbs (Angelicae Sinensis Radix, Paeoniae Radix Alba) in Cold Hypersensitivity in Hands and Feet.Life (Basel, Switzerland) · 2026Article
- Kaempferol's Therapeutic Applications and Mechanistic Insights in Ocular Diseases: Current Progress, Challenges, and Translational Opportunities.Pharmaceutics · 2026Review
- Antipyretic and Antinociceptive Activities of Tri-Phol-That Extract and Its Flavonoids:ACS omega · 2026Article
- Cellular reprogramming and signaling control by kaempferol in colorectal cancer.Discover oncology · 2026Review
- Review
- Integrating UHPLC-Q-TOF-MS, Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations to Reveal the Potential Mechanisms of Yiguanjian Decoction in Treating Liver Cancer.Chemistry & biodiversity · 2026Article
- LC-MS/MS-Based Comparative Phytochemical Profiling and Multivariate (PCA) Analysis of Seed Extracts fromInternational journal of molecular sciences · 2026Article
- Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance.MedComm · 2026Review
- Inhibition of proliferation and metastasis of nasopharyngeal carcinoma by kaempferol via down-regulation of c-Jun.Translational cancer research · 2026Article
- Kaempferol inhibits osteoclast differentiation and bone resorption by targeting the TNF-α/NF-κB and SRC/PI3K/AKT signaling pathways.Scientific reports · 2026Article
- A systems pharmacology-basedFrontiers in veterinary science · 2026Article
- [Kaempferol in improving chemotherapy-induced myelosuppression: A scoping review].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Anti-Inflammatory and Immunomodulatory Effects of Aqueous Extracts from Green Leaves and Rhizomes ofMolecules (Basel, Switzerland) · 2025Article
- Tiliroside Suppresses Uric Acid Production in Hepatocytes and Attenuates Purine-Induced Hyperuricemia in Male ICR Mice.Molecules (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kaempferol (KMF) is a dietary flavonoid exhibiting profound immunomodulatory effects across multiple immune cell populations. This review synthesizes current insights into how KMF regulates diverse immune cell populations and its therapeutic potential in inflammatory and immune-related disorders. KMF exhibits multifaceted effects on T cells. It inhibits T cell activation via suppressing various signaling pathways and calcineurin. Additionally, it regulates T cell subset balance through the modulation of different transcription factors. In natural killer (NK) cells, KMF enhances proliferation and cytotoxicity. This effect is partly mediated by gut microbiota modulation, which further boosts anti-tumor immunity. For dendritic cells (DCs), KMF shows context-dependent effects. It can promote adaptive immunity in some settings, while in inflammatory contexts, it suppresses DC maturation and cytokine secretion. KMF reduces neutrophil infiltration and the formation of neutrophil extracellular traps (NETs). It also alleviates eosinophil-driven allergic inflammation and blocks mast cell degranulation. Regarding macrophages, KMF shifts polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotypes in metabolic and fibrotic models. In cancer, however, it inhibits the polarization of tumor-associated M2 macrophages. Overall, KMF modulates multiple immune cell types and signaling pathways, positioning it as a promising candidate for treating autoimmune, inflammatory, and neoplastic diseases. Further translational research is warranted to explore its clinical utility and optimize delivery strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.